Results 121 to 130 of about 243,937 (306)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Study on the Work Hardening and Metamorphic Layer Characteristics of Milling Contour Bevel Gears. [PDF]
Materials (Basel), 2022 Wu M +6 more
europepmc +1 more source
Automated Grain Yield Behavior Classification [PDF]
A method for classifying grain stress evolution behaviors using unsupervised learning techniques is presented. The method is applied to analyze grain stress histories measured in-situ using high-energy X-ray diffraction microscopy (HEDM) from the ...
Beaudoin, Armand J. +5 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
A Data-Driven Approach for Studying the Influence of Carbides on Work Hardening of Steel. [PDF]
Materials (Basel), 2022 Vittorietti M +4 more
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Machining-Induced Work Hardening Behavior of Inconel 718 Considering Edge Geometries. [PDF]
Materials (Basel), 2022 Zhou B, Zhang W, Gao Z, Luo G.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Work Hardening Behavior and Microstructure Evolution of a Cu-Ti-Cr-Mg Alloy during Room Temperature and Cryogenic Rolling. [PDF]
Materials (Basel), 2023 Li R, Xiao Z, Li Z, Meng X, Wang X.
europepmc +1 more source
A Nonvolume Preserving Plasticity Theory with Applications to Powder Metallurgy [PDF]
, 1983 A plasticity theory has been developed to predict the mechanical response of powder metals during hot isostatic pressing. The theory parameters were obtained through an experimental program consisting of hydrostatic pressure tests, uniaxial compression ...
Cassenti, B. N.
core +1 more source