Results 131 to 140 of about 13,124,768 (302)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Design of work hardening basing on constraints

By classifying the composition/processing-microstructures-mechanical properties cycle into microstructural formation (MF) and property manifestation (PM), it is aimed to extend the understanding that work hardening is confined to the PM stage, proposing ...
F.H. Yu, P.P. Zhao, Feng Liu, H.Y. Liu, Dong-sheng Jia   +4 more
core   +1 more source

Influence of Work Hardening on the Surface of Backup Rolls for a 4-High Rolling Mill Fractured during Rolling Campaign. [PDF]

Materials (Basel), 2022
Servin-Castañeda R, Arreola-Villa SA, Perez-Alvarado A, Calderón-Ramos I, Torres-Gonzalez R, Martinez-Hurtado A.   +5 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Multiple deformation mechanisms induce high work hardening in Ti–5Al–7.5 V alloy via transformed β matrix

Materials Research Letters
In this work, different transformed β matrix was obtained in Ti–5Al–7.5 V alloy. The alloy with equiaxed αp phase and transformed β matrix containing α′ martensite and β phase exhibits good combination of strength and plasticity, as well as a high work ...
Sisi Xie, Zhihong Wu, Nana Chen, Mingxiang Zhu, Hao Yang, Zilong Zhang, Chuanyun Wang, Jinshan Li, Hongchao Kou   +8 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Grain-size insensitive work-hardening behavior of Ag microwires

, 2019
In this study, the work-hardening behavior of Ag microwires with different grain sizes has been investigated, and the results show that the work-hardening rate of Ag microwires does not decrease with the increase of grain size, suggesting that the work ...
Meng, Fanling, Lu, Jian, Yang, Haokun, Lu, Yang, Li, Xiaocui   +4 more
core   +1 more source

Critical Resolved Shear Stress and Work Hardening Determination in HCP Metals: Application to Zr Single Crystals

Metals
Obtaining precise parameters of deformation modes remains a significant challenge in materials science research. Critical resolved shear stresses (CRSS) and work hardening, particularly in hexagonal metals, are crucial parameters for constitutive laws in
Jean-Sébastien Lecomte, Jérôme Crépin, Pierre Barberis   +2 more
doaj   +1 more source

Work Hardening of Heat-Treated AlSi10Mg Alloy Manufactured by Selective Laser Melting: Effects of Layer Thickness and Hatch Spacing. [PDF]

Materials (Basel), 2021
Ghio E, Cerri E.
europepmc   +1 more source