Results 71 to 80 of about 1,809,942 (310)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Provocations: Putting philosophy to work on inclusion [PDF]

open access: yes, 2009
Inclusion is currently characterised by confusion about what it is supposed to be and do; frustration at the way the current climate of standards and accountability constrains teachers’ work; guilt at the exclusion created for individual pupils; and ...
Allan, Julie
core  

Promoting ethical design in small and medium-sized enterprises by an ethical design reflection workshop

open access: yesJournal of Responsible Innovation
Digital products and services are prevalent in daily life, increasing the responsibility of enterprises that create such technologies. Integrating ethical considerations into the design and development processes can promote responsible design and reduce ...
Veronica Hoth   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Mental health and work: dialogues on rights, desire, and need for access

open access: yesCadernos Brasileiros de Terapia Ocupacional, 2017
Introduction: Based on a research undertaken as part of a professional master’s degree, which aimed to studysocial inclusion through work in the context of Brazil’s Psychiatric Reform.
Ana Paula Donizete da Silva   +1 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Developing NQTs e-pedagogies for inclusion [PDF]

open access: yes, 2011
ESCalate Developing Pedagogy and Practice grant awarded to Nigel Beacham of the University of Aberdeen in 2009. Recently, the university has pioneered an approach to initial teacher education, to ensure that teachers have the pedagogical knowledge to ...
Beacham, Nigel
core  

Home - About - Disclaimer - Privacy