Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Fitting in : social inclusion in workplaces where people with intellectual disability are employed : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Rehabilitation at Massey University [PDF]
, 2003 Work is one important aspect of inclusion for people with intellectual disability. Success at work and inclusion in the culture of the workplace is a crucial step towards community membership.
Fillary, Rose
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Study of the Formation of Lamellar Cracks. [PDF]
, 2014 In rolled sheets, non-metallic inclusions are distributed along the thickness of the sheet as narrow lines running parallel to the rolling direction. Such inclusions are the nuclei of lamellar cracks.
Jaroniek, Mieczysław +1 more
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Journal of Responsible InnovationDigital products and services are prevalent in daily life, increasing the responsibility of enterprises that create such technologies. Integrating ethical considerations into the design and development processes can promote responsible design and reduce ...
Veronica Hoth +3 more
doaj +1 more source
Enhancing employment outcome among stable psychiatric patients: lesson learnt on innovative model of work inclusion. [PDF]
BMJ Open Qual, 2023 Khalid K, Jamaluddin R, Ismail MS.
europepmc +1 more source
Remote work and the professional inclusion of disabled people [PDF]
, 2007 Se analiza un panorama general sobre como el Teletrabajo puede ser un aporte a la inserción laboral de personas con discapacidad. El objetivo de este estudio consiste en analizar si el teletrabajo es una opción factible de ocupación laboral para personas
Salazar C., Cristian
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Mental health and work: dialogues on rights, desire, and need for access
Cadernos Brasileiros de Terapia Ocupacional, 2017 Introduction: Based on a research undertaken as part of a professional master’s degree, which aimed to studysocial inclusion through work in the context of Brazil’s Psychiatric Reform.
Ana Paula Donizete da Silva +1 more
doaj +1 more source