Results 61 to 70 of about 1,568,884 (267)
Management practice and disability: an embodied perspective
Scandinavian Journal of Disability Research, 2011 In organizational research, disability is most often treated as a hindrance for performance. One of the barriers to the employment of disabled people is the perceived extra costs related to adaptation of the physical work environment and reduced ...
Sara Värlander
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
BMC Health Services ResearchBackground The German healthcare system faces a persistent shortage of skilled professionals, particularly in nursing, driven by demographic change, high workloads, and challenging working conditions. In response, new working-time models such as the four-
Katharina Hast
doaj +1 more source
Remote work and hybrid work organizations
, 2022 Remote work, especially working from home, has become the most common form of work in the third decade of the 21st century. What started at the beginning of the millennium as an experimental practice in some companies (mainly in the IT industry) has become widespread and unintentional in 2020 and 2021, due to Covid 19 pandemic.
openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Managing the tasks of employees in the construction industry
Budownictwo o Zoptymalizowanym Potencjale Energetycznym, 2019 The proper organization of work is to set the workflow to the slightest effort of man and machine operation to obtain maximum results. The article presents the problem of the allocation personnel, that occurs in a real company that provides construction ...
Marek Krynke
doaj +1 more source