Results 141 to 150 of about 4,290,560 (312)

Working towards social participation

, 2021
PubliekssamenvattingWorking towards social participation – Sarita SanchesMensen met ernstige psychische aandoeningen ervaren veel problemen met betrekking tot maatschappelijke participatie. Onder maatschappelijke participatie wordt verstaan: deelname aan betaald werk, vrijwilligerswerk, opleiding of zinvolle dagbesteding.
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Work participation in adults with rare genetic diseases - a scoping review. [PDF]

BMC Public Health, 2023
Velvin G, Dammann B, Haagensen T, Johansen H, Strømme H, Geirdal AØ, Bathen T.   +6 more
europepmc   +1 more source

Increased Women's Labour Force Participation in Europe: Progress in the Work-Life Balance or Polarization of Behaviours? [PDF]

Although the increase in female labour force participation is a fairly widespread trend, there is still a considerable diversity of situations across Europe from north to south. To identify the factors that may explain these differences, Olivier Thévenon
Olivier Thevenon
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

What have we learned about risk assessment and interventions to prevent work-related musculoskeletal disorders and support work participation?

Scandinavian Journal of Work, Environment & Health
OBJECTIVE: The Scandinavian Journal of Work, Environment & Health (SJWEH) was established half a century ago. This paper provides an overview of research on musculoskeletal disorders (MSD) published over these 50 years.
P Paul FM Kuijer, Sten van der Wilk, Bradley Evanoff, Eira Viikari-Juntura, Pieter Coenen   +4 more
doaj   +1 more source

Do Caring Services Affect Off-Farm Work? Evidence from Italy [PDF]

The article investigates the determinants of the off-farm work decision in Italian farm households, highlighting the role of caring services. Assuming that the household simultaneously decides over the optimal allocation of time of each of its members, a
Parodi, Giuliana, Salvioni, Cristina, Sciulli, Dario   +2 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Documenting Work: From Participant Observation to Participant Tracing

, 2019
This paper explores the methodological aspects of studying distributed work by focusing on the more tangible aspects of this work, namely documents. We show how 1) researchers should engage in an initial mapping of documents before starting to track them; 2) the ongoing flow of virtual organizing only becomes apparent by triangulating the digital flow ...
Østerlund, C, Snyder, J, Sawyer, S, Sharma, S, Willis, M   +4 more
openaire   +1 more source