Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The effective participation of the audience in the production of news: encouraging opportunities through data journalism [PDF]
Digital tools allow and encourage users "to participate in the creation and circulation of media” (Lewis, 2012). This participation can be considered as a remedy against the growing disconnection between journalism and citizens, also as a formula for a ...
Blanco-Castilla, Elena Pilar +1 more
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Self-rated work ability predicts return to work after occupational rehabilitation
IntroductionWork ability assessments are important for planning, targeting, and executing occupational rehabilitation programs. The aim of the study was to examine whether a one-item self-rated Work Ability Score (WAS), assessed before and after ...
Chris Jensen +6 more
doaj +1 more source
Documenting Work: From Participant Observation to Participant Tracing [PDF]
This paper explores the methodological aspects of studying distributed work by focusing on the more tangible aspects of this work, namely documents. We show how 1) researchers should engage in an initial mapping of documents before starting to track them; 2) the ongoing flow of virtual organizing only becomes apparent by triangulating the digital flow ...
openaire +1 more source
Bolder Together 2: Building Grassroots Movements for Change [PDF]
California's demographics are changing fast, but rates of voting and civic participation haven't kept up. In four rapidly growing counties across the state, a group of funders is working with local organizations to support diverse communities to lift up ...
Cathy Cha, William H. Woodwell, Jr.
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Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Assessing the Evidence About Work Support Benefits and Low-Income Families [PDF]
Reviews research on factors affecting participation in work supports such as Medicaid, Children's Health Insurance, Supplemental Nutrition Assistance, and childcare subsidy programs; the programs' payoff, and state benefits of modernized delivery ...
Gregory Mills +2 more
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Empowering Women through Education and Influence: An Evaluation of the Indian Mahila Samakhya Program [PDF]
This paper shows that participation in a community-level female empowerment program in India significantly increases participants' physical mobility, political participation, and access to employment.
Arends-Kuenning, Mary P. +2 more
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