Results 121 to 130 of about 15,382,807 (261)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Workplace Intervention to Strengthen Supervisor Support for Employees With Common Mental Health Problems: A Mixed-Methods Realist Evaluation

Scandinavian Journal of Work and Organizational Psychology
The purpose of this study is to obtain insight into whether, how and under which circumstances a novel workplace intervention works. This intervention aims to strengthen the supportive behaviour of Dutch supervisors in promoting the work participation of
Suzanne Van Hees, Bouwine Carlier, Margot Joosen, Roland Blonk, Shirley Oomens   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Do Caring Services Affect Off-Farm Work? Evidence from Italy [PDF]

The article investigates the determinants of the off-farm work decision in Italian farm households, highlighting the role of caring services. Assuming that the household simultaneously decides over the optimal allocation of time of each of its members, a
Salvioni, Cristina, Parodi, Giuliana, Sciulli, Dario   +2 more
core  

Occupational differences in working life expectancy and working years lost in Nordic countries

Scandinavian Journal of Work, Environment & Health
OBJECTIVE: Risk of exit from work is both occupation- and country-specific. This study investigated occupational differences in working life expectancy (WLE) and reasons for working years lost (WYL) among employed workers in three Nordic countries ...
Karina Undem, Taina Leinonen, Daniel Falkstedt, Gun Johansson, Jacob Pedersen, Eira Viikari-Juntura, Ingrid Sivesind Mehlum, Svetlana Solovieva   +7 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Informal care, labour force participation and unmet needs for formal care in the EU-27, Croatia and Turkey. ENEPRI Research Report No. 97, November 2011 [PDF]

, 2011
This study seeks to estimate the effects of problems in labour force participation and unmet needs for formal care on informal caregiving. Using information for 2007 from Eurobarometer 283/Wave 67.3 for the EU-27 and the two candidate countries, Turkey ...
Prieto, Cristina Vilaplana
core  

Implemented disability-related policies and practices and sustained employment of partially disabled employees: evidence from linked survey and register data

Scandinavian Journal of Work, Environment & Health
OBJECTIVES: This study examined the associations between implemented disability-related policies and practices (DPP) and sustained employment among partially disabled employees in The Netherlands.
Raun van Ooijen, Pierre WC Koning, Cécile RL Boot, Sandra Brouwer   +3 more
doaj   +1 more source