Results 111 to 120 of about 15,382,807 (261)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Navigating urban mobility: Mobility attitudes and travel mode choices in Dubai and Lahore

Transport Economics and Management
Understanding the complexities of urban travel behaviors is essential for fostering sustainable mobility systems. This study examines the impact of socio-economic factors, attitudinal variables, and urban characteristics on travel mode choices for ...
Abdul Ghaffar Chaudhry, Houshmand Masoumi, Hans-Liudger Dienel, Atif Bilal Aslam, Mariam Shahnaz, Muhammad Ahmad, Mehtab Hussain   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Works Councils and the Productivity Impact of Direct Employee Participation [PDF]

This paper measures the productivity impact of management-led participative establishment practices. On the basis of a representative German establishment data set, the IAB establishment panel, the study finds that the presence of team-work, a reduction ...
Zwick, Thomas
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Approaches to Youth Participation in Youth and Community Work Practice: a Critical Dialogue

, 2020
Participation, and the inclusion of young people in decisions that affect them, is important to professional youth and community work practice (Smith 1983, 1988; Jeffs & Smith 1987; Irving, Maunders & Sherrington 1995; Harrison & Wise 2005; Ord 2007 ...
Corney, Tim, Holdsworth, Roger, Shier, Harry, Williamson, Howard, et al.   +4 more
core  

Part one: Social work political participation: A South African study

, 2000
This paper is based on a study which examined the political participation of social workers in KwaZulu-Natal. Part One presents the major findings and the need for a follow-up study .
Van Rooyen, CAJC, Gray, MMA
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Gendered effects of work and participation in collective forest management [PDF]

This paper reports the results of a statistical investigation of the relationship between labor time expended in rural livelihoods, social structure, and community forest management.
Naidu, Sirisha C.
core  

Participation as a tool for interactional work on Twitter: A sociolinguistic approach to social media 'engagement' [PDF]

, 2013
This work approaches the concept of social media engagement through a lens of participation theory. Following the work of Goffman (1981) and others, this dissertation uses the concepts of the participation framework and the participant role to explore ...
Draucker, Fawn
core