Results 131 to 140 of about 29,015,449 (345)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Effect of Discipline and Work Environment Performance of Paramedics (Case Study of Regency Hospital Arifin Achmad Pekanbaru) [PDF]

open access: yes, 2014
This research aims to determine how the variables influence the discipline and work environments simultaneously and partially on the performance of nonnursing paramedical staff (case studies from hospitals Arifin Achmad Pekanbaru).The population is non ...
Wasnury, R. (Rendra)
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Objective Structured Clinical Examinations (OSCEs) As Predictors of Performance on Work-Based Placements [PDF]

open access: yes, 2010
In view of its social justice policy, London Metropolitan University (LMU) actively encourages applicants from non-traditional backgrounds, therefore attracting a high percentage of mature students, many of whom have been out of formal education for ...
Wanstall, Heather
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

PENGARUH WORK-LIFE BALANCE DAN MOTIVASI TERHADAP KINERJA KARYAWAN [PDF]

open access: yes
Employee performance is essential in achieving organizational goals. Work-life balance and motivation need to be considered in supporting employee performance. The purpose of this research is to find out whether there is an influence of work-life balance
Azhar, Muhammad Rizky Zuhair
core  

Motivation to work performance [PDF]

open access: yes, 2015
Bakalářská práce se zabývá vztahem mezi motivací a pracovním výkonem. Cílem bakalářské práce je analýza motivace k pracovnímu výkonu ve vybraném podniku a současně návrh praktických doporučení pro zlepšení, se zaměřením pozornosti na několik klíčových ...
Sulanová Karolína
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

PENGARUH GAYA KEPEMIMPINAN, DISIPLIN KERJA, DAN KOMPENSASI TERHADAP KINERJA KARYAWAN (Studi Kasus Pada Toko Bang Ahmad Kab. Jombang) [PDF]

open access: yes
This study aims to: (1) Understand Employee Performance, Leadership Style, Work Discipline, and Compensation at Ahmad's store. (2) Understand the direct influence of Leadership Style on Employee Performance.
Attamyizu, Muhammad Zamzam
core  

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