Results 91 to 100 of about 2,856,159 (344)

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

Physics in Riemann's mathematical papers

, 2017
Riemann's mathematical papers contain many ideas that arise from physics, and some of them are motivated by problems from physics. In fact, it is not easy to separate Riemann's ideas in mathematics from those in physics.
A-M Legendre, AM Polyakov, AM Polyakov, B Riemann, B Riemann, B Riemann, B Riemann, B Riemann, C Reid, CF Gauss, CF Gauss, E Scholz, G Roch, GD Garland, GL Dirichlet, H Helmholtz von, H Weyl, I Kant, J Fourier, J. Dieudonné, History of algebraic geometry: An Outline of the History and Development of Algebraic Geometry, English translation by J. Sally, Wadsworth, Monterey, CA, JC Maxwell, JD Zund, JF Herbart, LV Ahlfors, MF Atiyah, P Dugac, P Stäckel, R Calinger, R Dedekind, R Farwell, R Narasimhan, RC Penner, SD Poisson, V-A Puiseux, V-A Puiseux, WH Meeks III   +35 more
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

ScotGrid: A Prototype Tier 2 Centre

, 2004
ScotGrid is a prototype regional computing centre formed as a collaboration between the universities of Durham, Edinburgh and Glasgow as part of the UK's national particle physics grid, GridPP.
Clark, P., Earl, A., Thorn, S.
core   +1 more source

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

Les Lumières Écossaises et le roman philosophique de Descartes [PDF]

, 2000
The paper reconstructs the reception of Descartes's work by the Scottish Enlighteners, from Colin MacLaurin to Dugald Stewart. The Scots' image of Descartes was a byproduct of a scientific controversy; philosophical arguments were brought into
Cremaschi, Sergio Volodia Marcello
core   +2 more sources

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Factors that affect the physical science career interest of female students: Testing five common hypotheses

Physical Review Special Topics. Physics Education Research, 2013
There are many hypotheses regarding factors that may encourage female students to pursue careers in the physical sciences. Using multivariate matching methods on national data drawn from the Persistence Research in Science and Engineering (PRiSE) project
Zahra Hazari, Geoff Potvin, Robynne M. Lock, Florin Lung, Gerhard Sonnert, Philip M. Sadler   +5 more
doaj   +1 more source

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, EarlyView.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source