Results 61 to 70 of about 232,611 (270)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Food pricing and consumer choice

Journal of Agriculture, Food Systems, and Community Development
Summary This policy and practice brief summarizes input from over 95 participants in the Fruit and Vege­table (Veggie) Policy Convening hosted by A Red Circle and University of Missouri Extension over two and a half days in February 2024. The purpose
Erica Williams, Participants of the 2024 Fruit and Vegetable Policy Convening, Lyndsey Ellis, Sagata Chatterjee, Thi Nguyen, Sarah Anderson   +5 more
doaj   +3 more sources

Thai Fathers’ Involvement in Childcare During Early Childhood: A Mixed-Methods Study

American Journal of Men's Health
This explanatory sequential mixed-methods study investigates the factors influencing Thai fathers’ involvement in early childhood Childcare. In the quantitative phase ( n  = 230), fathers’ involvement in Childcare was assessed using a Childcare ...
Atcharawadee Sriyasak, Chularat Howharn, Phatcharee Chookunhom, Varunee Ket-in, Atiya Sarakshetrin   +4 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The Analysis of Job Satisfaction of Health Practitioners in Saudi Arabia: Determinants and Strategic Recommendations for Health Workforce Planning [PDF]

, 2023
Talal Alotaibi, Mohammed A. Alsahafi, Osama M. Alariany, Ayman A.S. Alqarni, Maha Abuzenada, Eman Almutairi, Ziad M. Nakshabandi, Fahad Alyami, Basim Alsaywid, Miltiadis D. Lytras   +9 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Adaptation to a landscape-scale mountain pine beetle epidemic in the era of networked governance: the enduring importance of bureaucratic institutions

Ecology and Society, 2017
Landscape-scale forest disturbance events have become increasingly common worldwide under the combined influences of climate change and ecosystem modification.
Jesse B. Abrams, Heidi R. Huber-Stearns, Christopher Bone, Christine A. Grummon, Cassandra Moseley   +4 more
doaj   +1 more source

A crucial need for social, economic, and psychological investment to safeguard healthcare workforce

, 2021
AbhijitVinodrao Boratne, Manish Taywade, Amrit Mishra   +2 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source