Results 81 to 90 of about 1,115,558 (288)

Cost-efficient staffing under annualized hours [PDF]

, 2012
We study how flexibility in workforce capacity can be used to efficiently match capacity and demand. Flexibility in workforce capacity is introduced by the annualized hours regime.
Berden, Hubert J.J.M., Berrevoets, Leo M., Hans, Erwin W., Veen, Egbert van der, Veltman, Bart   +4 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A Loss Cycle of Burnout Symptoms and Reduced Coping Self-Efficacy: A Latent Change Score Modelling Approach

Chronic Stress
Police officers are frequently faced with chronic and acute stressors, such as excessive workload, organizational stressors and emotionally charged reports.
Liselotte M.J. Koning-Eikenhout, Roos Delahaij, Wim Kamphuis, Inge L. Hulshof, Joris Van Ruysseveldt   +4 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Collective Impact Case Study: Partners for a Competitive Workforce [PDF]

, 2013
Partners for a Competitive Workforce (PCW) supports a collective impact initiative that marries workforce development with employer demand -- accelerating the ability of each to solve their own challenges and those of the ...

core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Developing Compassionate Leadership in the UK in Healthcare Contexts: A Narrative Review of Leadership Programmes and Outcomes

Journal of Healthcare Leadership
Jonathan Minh Phuong,1 James Higgerson,1 Emma LT Pearce,1 Sarah C Willis,2 Ellen Ingrid Schafheutle1 1Centre for Pharmacy Workforce Studies, School of Health Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, M13 ...
Phuong JM, Higgerson J, Pearce ELT, Willis SC, Schafheutle EI   +4 more
doaj  

Thai Fathers’ Involvement in Childcare During Early Childhood: A Mixed-Methods Study

American Journal of Men's Health
This explanatory sequential mixed-methods study investigates the factors influencing Thai fathers’ involvement in early childhood Childcare. In the quantitative phase ( n  = 230), fathers’ involvement in Childcare was assessed using a Childcare ...
Atcharawadee Sriyasak, Chularat Howharn, Phatcharee Chookunhom, Varunee Ket-in, Atiya Sarakshetrin   +4 more
doaj   +1 more source

Nurse led care [PDF]

, 2005
What's the difference between medical and nursing care? The answer is not straightforward, but shortages in the medical workforce mean that nurses are increasingly called on to undertake work that was previously done by doctors (such as undertaking ...
Cullum, N, Richardson, G, Spilsbury, K
core   +2 more sources