Results 101 to 110 of about 3,812,558 (339)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

open access: yesFEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Le vote ouvrier et l’élection de Donald Trump : histoire et limites du discours populiste

open access: yesRevue LISA, 2018
This article examines the voting behavior of the white working class in the deindustrialized regions of the Northeast and Midwest in 2016. Although recent evolutions in American politics may account for the pro-Trump vote in the Rust Belt states, this ...
Tamara Boussac
doaj   +1 more source

Is a Growing Middle Class Good for the Poor? Social Policy in a Time of Globalization [PDF]

open access: yes, 2017
We examine the effect of the rise and evolution of the middle class on extreme poverty, using the World Bank's international poverty line of $1.90 per person per day in 2011 purchasing power parity (PPP)- adjusted terms.
Homi Kharas, Raj M. Desai
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Disparities in veterinary education: a survey comparing first-generation and continuing-generation students in Germany

open access: yesFrontiers in Veterinary Science
IntroductionAlthough university education in Germany is without tuition fees, the parental educational background influences the decision to study as well as the choice of subjects, and is linked to challenges that students face during the course of ...
Alexandra Gloria Kracht   +2 more
doaj   +1 more source

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