Results 121 to 130 of about 4,218,234 (309)

Spider Diagrams of Order and a Hierarchy of Star-Free Regular Languages [PDF]

, 2008
The spider diagram logic forms a fragment of the constraint diagram logic and was designed to be primarily used as a diagrammatic software specification tool.
Simon Thompson, John Taylor, Taylor, John, Delaney, Aidan, Thompson, Simon, Aidan Delaney   +5 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A thread-tag based semantics for sequence diagrams [PDF]

, 2007
The sequence diagram is one of the most popular behaviour modelling languages which offers an intuitive and visual way of describing expected behaviour of object-oriented software.
Dan, H, Robert M. Hierons, Haitao Dan, Steve Counsell, Hierons, RM, Counsell, S   +5 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Better Use Case Diagrams by Using Work System Snapshots

International Journal of Information Technologies and Systems Approach, 2016
Research to date shows significant variability in the success of applying the common technique of use case diagramming for identifying information system scope in terms of use cases performed by actors interacting with an information system or performed automatically by the information system.
Bolloju, Narasimha, Alter, Steven
openaire   +3 more sources

What Can Spider Diagrams Say? [PDF]

, 2004
Spider diagrams are a visual notation for expressing logical statements. In this paper we identify a well known fragment of first order predicate logic, that we call ESD, equivalent in expressive power to the spider diagram language.
Howse, John, Simon Thompson, John Taylor, Taylor, John, Gem Stapleton, John Howse, Thompson, Simon, Stapleton, Gem   +7 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Assisting Stakeholders in Class Diagram Interpretation with LLMs: a Work in Progress

2025 IEEE 33rd International Requirements Engineering Conference Workshops (REW)
Diagrams can be valuable tools in requirements engineering to establish a shared understanding between software engineers and stakeholders. However, interacting with these visual representations can be challenging for some stakeholders who prefer textual descriptions and may need support to inter- pret notation elements and understand the diagram ...
Mannari, C., Turchi, T., Bacco, M., Malizia, A.   +3 more
openaire   +3 more sources

Fine-Tuned LLMs Versus Rule-Based NLP for UML Diagram Generation: An Educational Evaluation

IEEE Access
The automatic generation of Unified Modeling Language (UML) diagrams from natural language requirements continues to be a difficult task in software engineering education and practice.
Reshma P. Nair, M. G. Thushara, Vijayan Sugumaran   +2 more
doaj   +1 more source