Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
TRANSFER OBJECTS USED IN THE PROCESSING OF COMPLEX EROSION [PDF]
The construction and form of the transfer object depend on process parameters and influence the technological parameters and the state parameters of the process. The most frequently used form of transfer object is the disk form.
Alin NIOAȚĂ
doaj
Regeneration experiments below 10K in a regenerative-cycle cryocooler [PDF]
At temperatures below 10K, regenerative cycle cryocoolers are limited by regeneration losses in the helium working fluid which result from the decreasing heat capacity of the regenerating material and the increasing density of helium.
Paulson, D. N., Sager, R. E.
core +1 more source
Fluid-Structure Interaction Simulation of a Coriolis Mass Flowmeter using a Lattice Boltzmann Method [PDF]
In this paper we use a fluid-structure interaction (FSI) approach to simulate a Coriolis mass flowmeter (CMF). The fluid dynamics are calculated by the open source framework OpenLB, based on the lattice Boltzmann method (LBM). For the structural dynamics
Haussmann, Marc +4 more
core +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Experimental investigation of small diameter two-phase closed thermosyphons charged with water, FC-84, FC-77 and FC-3283 [PDF]
Copyright © 2009 Elsevier Ltd. All rights reserved.An experimental investigation of the performance of thermosyphons charged with water as well as the dielectric heat transfer liquids FC-84, FC-77 and FC-3283 has been carried out. The copper thermosyphon
Jouhara, H, Robinson, AJ
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Investigation of Micro Porosity Sintered wick in Vapor Chamber for Fan Less Design [PDF]
Micro Porosity Sintered wick is made from metal injection molding processes, which provides a wick density with micro scale. It can keep more than 53 % working fluid inside the wick structure, and presents good pumping ability on working fluid ...
Kang, S. W., Wei, W. C., Yu, C. S.
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source

