Results 91 to 100 of about 5,382,061 (295)

Working fluid selection for the geothermal-solar hybrid cycle at Olkaria II power plant in Kenya. [PDF]

Heliyon, 2023
Venomhata HDV, Oketch PO, Gathitu BB, Chisale P.   +3 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Effect of Working Fluid on Characteristics of Organic Rankine Cycle with Medium Temperature Geothermal Water

Energies
The total installed geothermal power plant capacity at year-end 2023 was 16,335 MW, while the forecast for the installed capacity in 2025 is 19,331 MW. In Croatia, several medium-temperature geothermal resources (geothermal water) with temperatures from ...
Zvonimir Guzović, Zlatko Bačelić Medić, Marina Budanko   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Performance Analysis of a Solar–Air Source Absorption Heat Pump with Different Working Fluids

Energies
A solar–air source absorption heat pump (SAAHP), which mainly consists of a solar collector, a fan coil, and an absorption heat pump equipped with a gas-fired combustor, was proposed for water heating. This system runs in either SD (solar-energy-driving)
Yiqun Li
doaj   +1 more source

Multi-Objective Optimization of the Basic and Regenerative ORC Integrated with Working Fluid Selection. [PDF]

Entropy (Basel), 2022
Zhou Y, Ruan J, Hong G, Miao Z.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

21st Australasian Fluid Mechanics Conference (AFMC 2018)

, 2018
Fluid Structure Interactions (FSI), if not managed appropriately are known to have contributed to the loss of several aerospace vehicles. As done for the X-43, FSI can be designed-out by making structures sufficiently rigid and by providing appropriate ...
Jacobs, P., Jahn, I.H.J., Currao, G.M.D., Gollan, R., Neely, A.J.   +4 more
core   +1 more source

Experimental Evaluation of Working Fluid Damage to Gas Transport in a High-Rank Coalbed Methane Reservoir in the Qinshui Basin, China. [PDF]

ACS Omega, 2023
Liu D, Lin C, Guo B, Liu Q, Ma F, Wang Q, Wei C, Wang L, Jia D.   +8 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source