Results 111 to 120 of about 287,037 (310)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Performance Analysis of a Solar–Air Source Absorption Heat Pump with Different Working Fluids

Energies
A solar–air source absorption heat pump (SAAHP), which mainly consists of a solar collector, a fan coil, and an absorption heat pump equipped with a gas-fired combustor, was proposed for water heating. This system runs in either SD (solar-energy-driving)
Yiqun Li
doaj   +1 more source

Working fluid selection for the geothermal-solar hybrid cycle at Olkaria II power plant in Kenya. [PDF]

Heliyon, 2023
Venomhata HDV, Oketch PO, Gathitu BB, Chisale P.   +3 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A thermodynamic criterion for selection of working fluid for subcritical and supercritical domestic micro CHP

, 2010
International audienceA thermodynamic criterion for selection of a fluid both for subcritical and supercritical organic Rankine cycle has been proposed.
Mikielewicz, Dariusz, Dariusz Mikielewicz, Jarosław Mikielewicz, Mikielewicz, Jarosław   +3 more
core   +1 more source

Experimental Evaluation of Working Fluid Damage to Gas Transport in a High-Rank Coalbed Methane Reservoir in the Qinshui Basin, China. [PDF]

ACS Omega, 2023
Liu D, Lin C, Guo B, Liu Q, Ma F, Wang Q, Wei C, Wang L, Jia D.   +8 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Computational Fluid Dynamics based Analysis of a Closed Thermo-Siphon Hot Water Solar System

One of the alternative sources of energy is solar energy which is available in abundance throughout the world. The energy contained within the solar rays is capable of starting natural convection within closed mechanical systems containing a suitable ...
Freegah, Basim, Asim, Taimoor, Mishra, Rakesh   +2 more
core  

Experimental Results of a Newly Developed Very High Temperature Industrial Heat Pump (140°C) Equipped With Scroll Compressors and Working With a New Blend Refrigerant

, 2012
During last decades more and more attention has been paid on CO2 emissions. One of the solutions for decreasing CO2 emissions concerns the substitution of fossil fuels industrial boilers by the use of very high temperature electrical heat pumps. Moreover,
Bourig, Ali, Bobelin, Damien
core