Results 81 to 90 of about 5,382,061 (295)

Hazards of organic working fluids [PDF]

, 1977
We present several brief reviews on working fluids proposed for use in organic Rankine and bi-phase bottoming cycles. There are several general problems with many organic working fluids: flammability, toxicity, and a tendency to leak through seals.
openaire   +2 more sources

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Review of Reservoir Damage Mechanisms Induced by Working Fluids and the Design Principles of Reservoir Protection Fluids: From Oil–Gas Reservoirs to Geothermal Reservoirs

Energies
Various working fluids are applied during geothermal reservoir development, and geothermal reservoir damage induced by contacts between working fluids and reservoir formations are inevitable.
Ou Jiang, Ling Cao, Wenxi Zhu, Xiuhua Zheng   +3 more
doaj   +1 more source

Prospective lines of improving the process of evaluating the technical condition of aircraft hydraulic system working fluid

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2017
The article is devoted to the evaluation of the technical condition of aircraft hydraulic system working fluids. Working fluid parameters (concentration of impurities, viscosity, density, anti-oxidation, anti-wear and thermal properties) determining its ...
A. N. Koptev, A. M. Gareyev, I. A. Popelnyuk   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Working Knowledge for Fluid Management

THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA, 2010
麻酔中の輸液は血管内輸液，間質への輸液，細胞内への輸液の3本立てで考える．細胞外液製剤はブドウ糖以外の糖を浸透圧調整のため含んでいる製剤が容量効果と利尿効果をもっているので使いやすい．ヒドロキシエチルスターチ（HES）は血管内輸液として適切である．膠質浸透圧は測定膜，内皮細胞臓器特異性，病態を考慮する必要がある．HESには抗炎症作用があり，末梢循環を維持することができる．6% HES70は腎や止血凝固への影響は最も少ない．輸液のモニターとして尿量が臨床的である．圧モニターとしてのCVPより経食道心エコー下の容量負荷を重視した考え方がある．混合静脈血酸素飽和度や乳酸値は輸液を含めた周術期管理の総合的なモニターとして重要である．
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source