Results 91 to 100 of about 1,252,896 (260)
Research of the vacuum brake booster working process
Қарағанды университетінің хабаршысы. Физика сериясыThe creation of a laboratory installation was carried out with an aim to ensure the study of the working processes and characteristics of vacuum boosters as a part of hydraulic brake drives for vehicles with a gross weight of up to 3.5 tons for civilian
Н. Скляров +6 more
doaj +1 more source
Team Work in Protein Processing
Chemistry & Biology, 2007 MetAP substrates and their physiological roles have remained elusive. In this issue of Chemistry & Biology, Hu and colleagues [1] employ a small molecule approach to study the impact of MetAP inhibition on the molecular regulation and cellular functions of the proto-oncogene c-Src.
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
JSP: Jurnal Ilmu Sosial dan Ilmu PolitikThis study examines the claim that the benefits of good corporate governance (GCG) extend to all stakeholders, with a specific focus on the advantages for workers during operational processes.
Ardiyansyah Ardiyansyah
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Work processes - A work in process - Building a new work processes PSF for Petro-HRA
, 2015 This master thesis examines management support and safety culture in order to create a suggestion for a new PSF in Petro-HRA. Building on SPAR-H, the work processes PSF is examined and two select factors, management support and safety culture, are chosen for review.
openaire +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source