Results 71 to 80 of about 4,694,239 (258)

PERFORMANCE EVALUATION OF MULTIPURPOSE ELECTRIC COLLECTORS AS PROTECTION FRAMES OF AIR OF A WORKING ZONE AT DRAWING OF ELECTRODEPOSITS

Вестник Донского государственного технического университета, 2018
Research results of the efficiency of multipurpose superterranean electrocatchers of harmful galvanic sprays with various geometry of electrodes and electric fields are presented.
Vladimir L. GAPONOV, Vladimir I. GARSHIN
doaj  

Magnitude of Turnover Intention and Associated Factors among Health Professionals Working in Public Health Institutions of North Shoa Zone, Amhara Region, Ethiopia

BioMed Research International, 2018
Background Health workers are one of the most important building blocks of the health system. High turnover rate contribute to the shortfalls and unbalanced distribution of health personnel in the health workforce.
Aster Ferede, G. Kibret, Yihenew Million, Muluye Molla Simeneh, Yihalem Abebe Belay, D. Hailemariam   +5 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Risk Identification Method and Application of Roof Water Inrush Under Multi-Working Face Mining

Applied Sciences
Adjacent, multi-working face mining can expand the range of disturbed overburden, increasing the risk of triggering roof water inrush, which threatens the safe operation of coal mines. In this paper, we propose a risk identification method for roof water
Zhendi Huang, Kun Wang, Xuesheng Liu, Yongqiang Zhao, Xuebin Li, Biao Fu, Yu Zhou   +6 more
doaj   +1 more source

Optimization of index gases and division method of spontaneous combustion 'three zones' in 10 coal seam of Qingdong Coal Mine

Gong-kuang zidonghua, 2018
In view of problem of natural fire on 1078 working face of Qingdong Coal Mine, through a combination of laboratory research and on—site testing, the main and auxiliary indicators of spontaneous combustion index gases were optimized: CO and C2H4 can be ...
SUN Liutao, DUAN Yujian, HUANG Junze
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Job related stress among nurses working in Jimma Zone public hospitals, South West Ethiopia: a cross sectional study

BMC Nursing, 2016
BackgroundOccupational stress exists in every profession, nevertheless, the nursing profession appears to experience more stress at work compared to other health care workers.
Tadesse Dagget, Ashagre Molla, T. Belachew   +2 more
semanticscholar   +1 more source