Results 91 to 100 of about 1,198,222 (315)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An evaluation of a global vitamin and mineral nutrition surveillance system

Archivos Latinoamericanos de Nutrición
Evaluation at all levels is a fundamental function at World Health Organization (WHO). Evaluation of public health surveillance systems is essential to ensure that problems of public health importance are monitored efficiently and effectively.
Nancy Jennings Aburto, Lisa Rogers, Luz Maria De-Regil, Vipat Kuruchittham, Grace Rob, Raheel Arif, Juan Pablo Peña-Rosas   +6 more
doaj  

Polio eradication in Nigeria: evaluation of the quality of acute flaccid paralysis surveillance documentation in Bauchi state, 2016

BMC Public Health, 2018
Background Nigeria is the only country in Africa that is yet to be certified as polio free. Surveillance for acute flaccid paralysis (AFP) is the foundation of the polio eradication initiative since it provides information to alert both health managers ...
Adamu Ibrahim Ningi, Faisal Shuaib, Luka Mangveep Ibrahim, Jalal-Eddeen Abubakar Saleh, Khalid Abdelrahim, Isah Mohammed Bello, Bashir Abba, Ticha Jonhson Muluh, Fiona Braka, Sisay G. Tegegne, Abdullahi Wallah, Charles Korir, Samuel Bawa, Mahmood Saidu, Peter Nsubuga   +14 more
doaj   +1 more source

Proposed programme and budget estimates for the financial year 1 January--31 December 1959 with the proposed programme and estimated expenditure for technical assistance for economic development of under-developed countries and the operations planned to be financed from the malaria eradication special account

, 1957
395 ...
World Health Organization
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Proposed programme and budget estimates for the financial year 1 January--31 December 1953 with the proposed programme and estimated expenditure for technical assistance for economic development of under-developed countries

, 1952
564 ...
World Health Organization
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Current global iodine status and progress over the last decade towards the elimination of iodine deficiency

Bulletin of the World Health Organization, 2005
OBJECTIVE: To estimate worldwide iodine nutrition and monitor country progress towards sustained elimination of iodine deficiency disorders. METHODS: Cross-sectional data on urinary iodine (UI) and total goitre prevalence (TGP) in school-age children ...
Maria Andersson, Bahi Takkouche, Ines Egli, Henrietta E. Allen, Bruno de Benoist   +4 more
doaj  

The relevance of research to the global antimalaria programme.

, 1977
13313
Wernsdorfer, W. H.
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source