Results 81 to 90 of about 1,198,222 (315)

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Global challenges and solutions to achieving and sustaining measles and rubella elimination

open access: yesRevista Panamericana de Salud Pública
Measles and rubella have long been recognized as priorities for disease prevention because of their devastating consequences for child health; hence, all World Health Organization (WHO) regions currently have a goal to eliminate measles and four out of ...
Natasha S. Crowcroft   +9 more
doaj   +1 more source

The role of supportive supervision using mobile technology in monitoring and guiding program performance: a case study in Nigeria, 2015–2016

open access: yesBMC Public Health, 2018
Background Supportive supervision is one of the interventions that fosters program improvement by way of imparting knowledge and skills to health workers.
Sisay G. Tegegne   +18 more
doaj   +1 more source

Nematode pathogens of Culicidae (mosquitos).

open access: yes, 1977
17318
Petersen, J. J.
core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Aldrin and dieldrin : health and safety guide

open access: yes, 1989
Companion volume to: Environmental health criteria ; 91Published by the World Health Organization for the International Programme on Chemical Safety48 ...
World Health Organization   +1 more
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

World Health Organization [PDF]

open access: yesInternational Organization, 1947
Designed as a collective instrument to raise the standards of health and well-being of all peoples throughout the world, a new World Health Organization was launched, under the auspices of the Economic and Social Council, by the International Health Conference, which met at Hunter College, June 19 to July 22, 1946.
openaire   +2 more sources

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