Results 101 to 110 of about 3,890,023 (314)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Eradication of poliomyelitis in countries affected by conflict

Bulletin of the World Health Organization, 2000
The global initiative to eradicate poliomyelitis is focusing on a small number of countries in Africa (Angola, Democratic Republic of the Congo, Liberia, Sierra Leone, Somalia, Sudan) and Asia (Afghanistan, Tajikistan), where progress has been hindered ...
R.H. Tangermann, H.F. Hull, H. Jafari, B. Nkowane, H. Everts, R.B. Aylward   +5 more
doaj  

Maintenance of behaviour change following a community-wide gamification based physical activity intervention [PDF]

, 2018
Gamification refers to the use of game mechanics (e.g. competition, point scoring, progress visualisation and task setting) to engage and motivate people to achieve an end goal.
Baker, Corepal, Cugelman, Demetrovics, Deterding, Guthold, Harris, Huotari, Johnson, King, LeBlanc, Lindqvist, Lister, Liu, Looyestyn, McCartney, Michie, Milton, Ng, Shameli, World Health Organization, World Health Organization, World Health Organization, Yang, Zuckerman   +24 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Global challenges and solutions to achieving and sustaining measles and rubella elimination

Revista Panamericana de Salud Pública
Measles and rubella have long been recognized as priorities for disease prevention because of their devastating consequences for child health; hence, all World Health Organization (WHO) regions currently have a goal to eliminate measles and four out of ...
Natasha S. Crowcroft, Anna A. Minta, Sebastien Antoni, Lee Lee Ho, William Perea, Mick N. Mulders, Anindya Sekhar Bose, Aaron Wallace, Diana Chang Blanc, Patrick M. O’Connor   +9 more
doaj   +1 more source

The role of supportive supervision using mobile technology in monitoring and guiding program performance: a case study in Nigeria, 2015–2016

BMC Public Health, 2018
Background Supportive supervision is one of the interventions that fosters program improvement by way of imparting knowledge and skills to health workers.
Sisay G. Tegegne, Faisal Shuaib, Fiona Braka, Pascal Mkanda, Tesfaye B. Erbeto, Aron Aregay, Oyaole D. Rasheed, Akpan G. Ubong, Njie Alpha, Ahmed Khedr, Mirghani A. Isameldin, Yared G. Yehushualet, Charity Warigon, Usman Adamu, Eunice Damisa, Bassey Okposen, Peter Nsubuga, Rui G. Vaz, Wondimagegnehu Alemu   +18 more
doaj   +1 more source

A Review of Dietary Zinc Recommendations [PDF]

, 2016
Background. Large discrepancies exist among the dietary zinc recommendations set by expert groups. Objective. To understand the basis for the differences in the dietary zinc recommendations set by the World Health Organization, the U.S.
Avellini BA, Brown KM, Brown KM, Cohn JR, European Food Safety Authority, European Food Safety Authority, Frye AJ, Hazelhurst LT, Heinig MJ, Institute of Medicine, World Health Organization/Food and Agricultural Organization, World Health Organization/Food and Agricultural Organization/International Atomic Energy Association   +11 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

World Health Organization [PDF]

International Organization, 1947
Designed as a collective instrument to raise the standards of health and well-being of all peoples throughout the world, a new World Health Organization was launched, under the auspices of the Economic and Social Council, by the International Health Conference, which met at Hunter College, June 19 to July 22, 1946.
openaire   +2 more sources

Understanding issues of people living with disabilities in South Africa [PDF]

, 2013
The problem of disabilities is growing all over the world. Nevertheless, some progress has been made since the year 1981 was proclaimed International Year of Disabled Persons.
Ahlburg D, British Council of Organizations of Disabled People, Cambois E, Desai AN, Kapteyan A, Mehta DS, Pathmanathan, Quinn G, World Health Organization, World Health Organization, World Health Organization, World Health Report   +11 more
core   +1 more source