Results 121 to 130 of about 1,198,222 (315)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

BRICS and global health: a call for papers

Bulletin of the World Health Organization, 2013
Pascal Zurn, Marie-Andrée Romisch-Diouf, Shambhu Acharya, Sarah Louise Barber, Natela Menabde, Luigi Migliorini, Joaquin Molina, Michael J O'Leary   +7 more
doaj   +1 more source

Expert Committee on the Unification of Pharmacopoeias : report of the fourth session, Geneva, 20 to 30 April 1949

, 1950
15 ...
World Health Organization. Expert Committee on the Unification of Pharmacopoeias, World Health Organization   +1 more
core  

Public Health

Efforts to understand and address the linkages between behavior and health outcomes have been an area of engagement in public health for decades. This joint report from the World Bank and the World Health Organization examines the complex ways in which ...
World Health Organization, World Bank
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

International Sanitary Regulations: proceedings of the Special Committee and of the fourth World Health Assembly on WHO Regulations no. 2

, 1952
443 ...
World Health Assembly, 4
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Implementation of co-trimoxazole prophylaxis and isoniazid preventive therapy for people living with HIV

Bulletin of the World Health Organization, 2010
OBJECTIVE: To measure progress in implementing co-trimoxazole prophylaxis (CTXp) (trimethoprim plus sulfamethoxazole) and isoniazid preventive therapy (IPT) policy recommendations, identify barriers to the development of national policies and pinpoint ...
Anand A Date, Marco Vitoria, Reuben Granich, Mazuwa Banda, Mayada Youssef Fox, Charlie Gilks   +5 more
doaj  

Permissible levels of occupational exposure to airborne toxic substances : sixth report of the Joint ILO/WHO Committee on Occupational Health [meeting held in Geneva from 4 to 10 June 1968]

, 1969
16 ...
World Health Organization, International Labour Organization, Joint ILO/WHO Committee on Occupational Health   +2 more
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source