Results 141 to 150 of about 177,955,801 (276)
Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota
Advanced Science, EarlyView.Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal +25 more
wiley +1 more source
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Advanced Science, EarlyView.Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
World rheumatism year [full issue]
, 1977 [31] p.Includes a brochure: "Forward together: appropriate technology for health" (6 p.)1977 World Rheumatism ...
World Health Organization
core
Machine Learning of Temperature‐Dependent Chemical Kinetics Using Parallel Droplet Microreactors
Advanced Science, EarlyView.An integrated droplet microfluidics and machine learning framework enables high‐throughput characterization of temperature‐dependent reaction kinetics. Time‐resolved measurements from thousands of droplets train Neural ODE models that accurately predict nonlinear reaction dynamics across diverse thermal environments, bridging large‐scale ...
Mamoru Saita, Yutaka Hori
wiley +1 more source
Supplementary report of the Interim Commission to the first World Health Assembly
, 1948 75 ...
World Health Organization, Interim Commission
core
Story in “the world of values”
Revista Ciencias Biomédicas, 2010 In the general scenario of those worrying social facts, it is common to turn to moralguidelines that let adjust the human behaviour according to the citizenship ethic sense. That sense is the result of the evaluation given to the perceived facts.
Olivera-Díaz Álvaro
doaj
Advanced Science, EarlyView.This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song +9 more
wiley +1 more source
WHO mental health activities : World Health Day, 7th April 2001
, 2000 "This document is intended for use by non-governmental organisations, professional and lay associations, universities, hospitals and other institutions who wish to organise an event in celebration of World Health Day 2001 on Mental Health"At head of ...
World Health Organization
core
Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy
Advanced Science, EarlyView.This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao +5 more
wiley +1 more source