Results 31 to 40 of about 736,084 (308)

Real-World Evidence on Disease Burden and Economic Impact of Sickle Cell Disease in Italy

Journal of Clinical Medicine, 2022
A real-world analysis was conducted in Italy among sickle cell disease (SCD) patients to evaluate the epidemiology of SCD, describe patients’ characteristics and the therapeutic and economic burden. A retrospective analysis of administrative databases of
L. De Franceschi, Chiara Castiglioni, C. Condorelli, D. Valsecchi, Eleonora Premoli, C. Fiocchi, V. Perrone, L. Esposti, G. Forni, On Behalf Of The GREATalyS Study Group   +9 more
semanticscholar   +1 more source

MUNDO DADO E MUNDO CONSTRUÍDO NA OBRA DE BERNARDO ÉLIS GIVEN WORLD AND BUILT WORLD IN THE WORK OF BERNARDO ÉLIS

Signótica, 2011
Este artigo constituiu-se por meio de pesquisa bibliográfica e qualitativa e tem o objetivo de relacionar os conceitos de mundo dado e mundo construído do historiador da religião Riolando Azzi com, respectivamente, o universo rural retratado por Bernardo
Leila Borges Dias Santos
doaj   +1 more source

Treatment Approaches and Outcome of Patients with Neuroendocrine Neoplasia Grade 3 in German Real-World Clinical Practice

Cancers, 2022
Simple Summary Grade 3 neuroendocrine neoplasms (NEN G3) are a rare and heterogeneous subtype of NEN and include poorly differentiated neuroendocrine carcinomas and well-differentiated neuroendocrine tumors G3 (NET G3).
S. Luecke, C. Fottner, H. Lahner, H. Jann, Dominik Zolnowski, D. Quietzsch, P. Grabowski, B. Cremer, S. Maasberg, U. Pape, H. Mueller, T. Gress, A. Rinke, The Members Of The German Net Registry   +13 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Factors associated with long-term retention of treatment with golimumab in a real-world setting: an analysis of the Spanish BIOBADASER registry

Rheumatology International, 2018
The retention rate of a biological drug (percentage of patients remaining on treatment over time) provides an index of a drug’s overall effectiveness.
María V. Hernandez, C. Sánchez-Piedra, B. García-Magallón, E. Cuende, J. Manero, Cristina Campos-Fernández, R. Martín-Doménech, J. Pino-Montes, S. Manrique, M. Castro-Villegas, D. Ruiz-Montesinos, F. Sánchez-Alonso, F. Díaz-González, L. cea-calvo, J. Gómez-Reino, O. B. O. I. R. Group   +15 more
semanticscholar   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

“«I Am Myself the Matter of my Book»: The Historical Evolution of the Essayistic-Argumentative Genre [PDF]

, 2016
Producción CientíficaABSTRACT: The current work seeks to explore the development of the essay in western culture as a means of reflecting the identity of the author.
Martín Jiménez, Alfonso
core   +3 more sources

The Time over the time: reflections on the challenges of contemporary society [PDF]

, 2014
En el presente ensayo, el autor reflexiona sobre el desarrollo de la sociedad internacional hasta nuestros días resaltando la forma en que las dos guerras mundiales del siglo XX, la Guerra Fría, la Caída del Muro de Berlín y ...
Díaz Müller, Luis T.
core   +3 more sources

Некоторые аспекты кодификации феномена современного славянского язычества по данным полевых исследований

Acta Baltico-Slavica, 2014
Some aspects of the codification phenomenon of contemporary Slavic paganism (in light of from field study material) On the basis of material received from a survey of three Russian pagan associations, the author  discusses some  features of ...
Роман [Roman] Шиженский [Shizhenskiĭ]
doaj   +1 more source

Pharmacometabolomics Enables Real-World Drug Metabolism Sciences

Metabolites
Background/Objectives: Pharmacogenomics (PGx) has revolutionized personalized medicine, notably by predicting drug responses through the study of the metabolic genotype of drug-metabolizing enzymes.
Fleur B Nijdam, Marieke A. J. Hof, H. Blokzijl, S. J. Bakker, E. Hak, G. Hopfgartner, F. Klont, On Behalf Of The TransplantLines Investigators   +7 more
semanticscholar   +1 more source