Results 101 to 110 of about 800,478 (355)

A multiscale model for collagen alignment in wound healing [PDF]

, 2005
It is thought that collagen alignment plays a significant part in scar tissue formation during dermal wound healing. We present a multiscale model for collagen deposition and alignment during this process. We consider fibroblasts as discrete units moving
Dallon, J. C., Maini, P. K., Sherratt, J. A.   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Decreased glomerular function is associated with disease severity in patients with hidradenitis suppurativa

Health Science Reports, 2022
Valdemar W. Nielsen, Yiqiu Yao, Jesper G. Holm, Astrid‐Helene R. Jørgensen, Hans C. Ring, Mads Hornum, Simon F. Thomsen   +6 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Specification and Misconception About COVID-19 Disappearing [PDF]

International Journal of Basic Science in Medicine, 2020
Amir Emami, Fatemeh Javanmardi, Neda Pirbonyeh, Abdolkhalegh Keshavarzi   +3 more
doaj   +1 more source

Investigating the Relationship Between the Use of Antibiotic Prophylaxis on Changes in Blood Factors, Mortality, Incidence of Infection and Drug Resistance in Burn Patients [PDF]

Armaghane Danesh Bimonthly Journal
Background & aim: The use of antibiotic prophylaxis in the treatment of burns is a controversial issue. Many specialists start antibiotic treatment after the patient is admitted to prevent infection, while in most cases, antibiotic use is not necessary ...
A Keshavarzi, M Ghaedi, A Emami, A Najafi, Z Rahgozar, M Zardosht, M Hamzehnejadi, R Mehdizade Tazangi, S Rajabpoor, M Dehbozorgi   +9 more
doaj  

Melatonin‐engineered MSCs‐exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival

Clinical and Translational Medicine
Background This study investigates the impact of sleep restriction (SR) on flap viability and its underlying mechanisms. It reveals that SR triggers clock rhythmic ferroptosis, which leads to impaired skin barrier function and increased flap necrosis ...
Xiaoqiong Jiang, Yu Wang, Xuanlong Zhang, Huiming Deng, Liangyu Fang, Chaire Tafadzwa, Jiangnan Yao, Hao Chen, Anqi Ye, Kailiang Zhou, Xiangwei Ling, Jian Xiao   +11 more
doaj   +1 more source

Atypical Diabetic Foot Ulcer Keratinocyte Protein Signaling Correlates with Impaired Wound Healing

Journal of Diabetes Research, 2016
Diabetes mellitus is associated with chronic diabetic foot ulcers (DFUs) and wound infections often resulting in lower extremity amputations. The protein signaling architecture of the mechanisms responsible for impaired DFU healing has not been ...
Glenn D. Hoke, Corrine Ramos, Nicholas N. Hoke, Mary C. Crossland, Lisa G. Shawler, Joseph V. Boykin   +5 more
doaj   +1 more source

WOUND HEALING AND COLLAGEN FORMATION [PDF]

, 1962
Russell Ross, Earl P. Benditt
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source