Results 121 to 130 of about 1,577,605 (357)

Ultra-Early versus Early Excision and Grafting for Thermal Burns up to 60% Total Body Surface Area; A Historical Cohort Study

Bulletin of Emergency and Trauma, 2016
Objective: To compare the outcome of patients with up to 60% total body surface area (TBSA) thermal burns undergoing ultra-early and early excision and grafting.
Abdolkhalegh Keshavarzi, Mehdi Ayaz, Maryam Dehghankhalili   +2 more
doaj  

Atypical Diabetic Foot Ulcer Keratinocyte Protein Signaling Correlates with Impaired Wound Healing

Journal of Diabetes Research, 2016
Diabetes mellitus is associated with chronic diabetic foot ulcers (DFUs) and wound infections often resulting in lower extremity amputations. The protein signaling architecture of the mechanisms responsible for impaired DFU healing has not been ...
Glenn D. Hoke, Corrine Ramos, Nicholas N. Hoke, Mary C. Crossland, Lisa G. Shawler, Joseph V. Boykin   +5 more
doaj   +1 more source

Heel Pressure Ulcers: a study of wound healing [PDF]

, 2011
Background Heels are a common location for pressure ulcers (PUs); they may be physiologically different to other PU sites and their healing is poorly understood. Aim To summarise the effects of support surfaces and identify prognostic factors in
McGinnis, Elizabeth
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Decreased glomerular function is associated with disease severity in patients with hidradenitis suppurativa

Health Science Reports, 2022
Valdemar W. Nielsen, Yiqiu Yao, Jesper G. Holm, Astrid‐Helene R. Jørgensen, Hans C. Ring, Mads Hornum, Simon F. Thomsen   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Specification and Misconception About COVID-19 Disappearing [PDF]

International Journal of Basic Science in Medicine, 2020
Amir Emami, Fatemeh Javanmardi, Neda Pirbonyeh, Abdolkhalegh Keshavarzi   +3 more
doaj   +1 more source

Investigating the Relationship Between the Use of Antibiotic Prophylaxis on Changes in Blood Factors, Mortality, Incidence of Infection and Drug Resistance in Burn Patients [PDF]

Armaghane Danesh Bimonthly Journal
Background & aim: The use of antibiotic prophylaxis in the treatment of burns is a controversial issue. Many specialists start antibiotic treatment after the patient is admitted to prevent infection, while in most cases, antibiotic use is not necessary ...
A Keshavarzi, M Ghaedi, A Emami, A Najafi, Z Rahgozar, M Zardosht, M Hamzehnejadi, R Mehdizade Tazangi, S Rajabpoor, M Dehbozorgi   +9 more
doaj  

Melatonin‐engineered MSCs‐exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival

Clinical and Translational Medicine
Background This study investigates the impact of sleep restriction (SR) on flap viability and its underlying mechanisms. It reveals that SR triggers clock rhythmic ferroptosis, which leads to impaired skin barrier function and increased flap necrosis ...
Xiaoqiong Jiang, Yu Wang, Xuanlong Zhang, Huiming Deng, Liangyu Fang, Chaire Tafadzwa, Jiangnan Yao, Hao Chen, Anqi Ye, Kailiang Zhou, Xiangwei Ling, Jian Xiao   +11 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source