Results 81 to 90 of about 895,077 (292)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Integrated Bulk and Single-Cell Transcriptomics Reveals Cell-Type-Specific Fatty Acid Metabolic Dysregulation and Candidate Biomarkers in Diabetic Foot Ulcers

Clinical, Cosmetic and Investigational Dermatology
Bo Hu, Jinghui Zhao, Shengnan Chai, Long ZhangWound Healing Center, Peking University Third Hospital, Beijing, 100191, People’s Republic of ChinaCorrespondence: Long Zhang, Wound Healing Center, Peking University Third Hospital, No. 49 Huayuan North Road,
Hu B, Zhao J, Chai S, Zhang L
doaj  

Prevalence of Colonization, Association With Disease Stage and Effect of Eradication of Staphylococcus aureus in Cutaneous T‐Cell Lymphoma: A Systematic Review and Meta‐Analysis

JEADV Clinical Practice
Background Cutaneous T‐cell lymphoma (CTCL) is a rare and heterogeneous group of skin‐homing lymphomas with a largely unknown pathogenesis. Staphylococcus aureus (S.
Ida Lind Holm, Sarah Søltoft Rasmussen, Somaia Naassan, Misbah N. Ghazanfar, Kenneth Thomsen, Rikke Bech, Lise M. Lindahl, Maria Kamstrup, Simon Francis Thomsen, Zarqa Ali   +9 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring [PDF]

, 2008
Previous studies of tissue repair have revealed osteopontin (OPN) to be up-regulated in association with the wound inflammatory response. We hypothesize that OPN may contribute to inflammation-associated fibrosis.
Mori, Ryoichi, Shaw, T.J, Tanya J. Shaw, Shaw, Tanya J., Martin, Paul, Shaw, TJ, Mori, R, Shaw, Tanya J, Paul Martin, Martin, P, Ryoichi Mori   +10 more
core   +1 more source

A Photothermally Triggered Nanoplatform for Multidimensional Antibacterial Therapy and Accelerated Healing of Infected Wounds

International Journal of Nanomedicine
Yueying Fan,1,* Jinfu Li,1,* Peng Wang,1,* Yuhuan Peng,1 Chao Yan,1 Xiangyang Li,1 Zhaoxiang Wang,1 Xiao Li,1 Zhanchen He,1 Wenqiang Li,2 Bin Yin,1 Chiyu Jia1 1Center of Burn & Plastic and Wound Healing Surgery, The First ...
Fan Y, Li J, Wang P, Peng Y, Yan C, Li X, Wang Z, Li X, He Z, Li W, Yin B, Jia C   +11 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Liver enzyme levels are associated with markers of systemic inflammation, disease severity, and metabolic syndrome in patients with hidradenitis suppurativa

Health Science Reports, 2021
Valdemar Wendelboe Nielsen, Jesper Grønlund Holm, Astrid‐Helene Ravn Jørgensen, Yiqiu Yao, Hans Christian Ring, Simon Francis Thomsen   +5 more
doaj   +1 more source

Human adipose-derived stem cell exosomes reduce mitochondrial DNA common deletion through PINK1/Parkin-mediated mitophagy to improve skin photoaging

Stem Cell Research & Therapy
Backgroud Mitochondrial DNA (mtDNA) deletion and oxidative stress are key contributors to skin photoaging. Mitophagy helps mitigate oxidative stress.
Yihao Wang, Wanxing Liao, Yiping Wang, Junlin Liao, Nian Chen, Chiyu Jia, Li Zeng   +6 more
doaj   +1 more source