Results 81 to 90 of about 68,858 (291)

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source

Liquiritigenin-loaded poly (acrylic acid)-carboxymethyl cellulose hydrogels: formulation optimization, performance evaluation, and assessment of therapeutic efficacy for wound healing and sepsis caused by wound bacterial infection

Frontiers in Bioengineering and Biotechnology
IntroductionBacterial wound infections that lead to sepsis pose a major clinical challenge. This study aims to develop and optimize a novel cross-linked poly(acrylic acid)/carboxymethylcellulose sodium (PAA/CMC-Na) hydrogel encapsulating liquiritigenin ...
Xiang Meng, Xiang Meng, Muzhou Xue, Zequn Zeng, Wenbin Pei, Bing Gong   +5 more
doaj   +1 more source

A rare image of spontaneous enterocutaneous fistula in morbidly obese patient with metabolic syndrome

The Pan African Medical Journal, 2015
32 year old lady, a morbidly obese grand multipara developed spontaneous enterocutaneous fistula. Wound around right para-umblical region started as boil, it ruptured and started discharging purulent pus associated fever, colicky central abdominal pain ...
Ballah Akawu Denue, Salihu Aliyu Kwayabura   +1 more
doaj   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Investigation of incidence and risk factors of post Caesarean section wound sepsis in Hlabisa hospital and implications to patients [PDF]

, 1997
Submitted to the Faculty of Arts in fulfilment of the requirements for the Degree of Master of Arts: Curationis in the Department of Nursing Science at the University of Zululand, 1997.The descriptive study on patients who developed post caesarean ...
Khathi, Abigail Nonhlanhla
core   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Do you know about sepsis? [PDF]

It\u2019s time to talk about sepsis. Why? Because any infection \u2013 like a wound, pneumonia, or a urinary tract infection \u2013 can lead to sepsis.Because sepsis is a medical emergency.If you or a loved one suspects sepsis or has an infection that ...

core  

Secondary bacterial infections of buruli ulcer lesions before and after chemotherapy with streptomycin and rifampicin [PDF]

, 2013
Buruli ulcer (BU), caused by Mycobacterium ulcerans is a chronic necrotizing skin disease. It usually starts with a subcutaneous nodule or plaque containing large clusters of extracellular acid-fast bacilli.
Kwabena Quenin-Fosu, Gerd Pluschke, Newman Mercy, Ruf, Marie-Thérèse, Cynthia Kwakye-Maclean (349465), Grace S. Kpeli, Asan-Ampah, Kobina, Mercy Newman (409617), Kwabena Quenin-Fosu (335716), Marie-Thérèse Ruf (2280196), Isaac Lamptey, Kwakye-Maclean Cynthia, Mercy Newman, Albert Paintsil (409614), Kpeli Grace S., Cynthia Kwakye-Maclean, Grace S. Kpeli (409612), Isaac Lamptey (409615), Dorothy Yeboah-Manu, Benjamin Anku, Pluschke, Gerd, Yeboah-Manu, Dorothy, Evelyn Owusu-Mireku, Marie-Thérèse Ruf, Dorothy Yeboah-Manu (120059), Grace S Kpeli, Anku Benjamin, Albert Paintsil, Owusu-Mireku Evelyn, Evelyn Owusu-Mireku (409613), Quenin-Fosu Kwabena, Owusu-Mireku, Evelyn, Lamptey, Isaac, Paintsil, Albert, Quenin-Fosu, Kwabena, Benjamin Anku (409616), Ruf Marie-Thérèse, Pluschke Gerd, Kwakye-Maclean, Cynthia, Gerd Pluschke (7855), Kobina Asan-Ampah (335715), Anku, Benjamin, Asan-Ampah Kobina, Yeboah-Manu Dorothy, Paintsil Albert, Kpeli, Grace S., Newman, Mercy, Lamptey Isaac, Kobina Asan-Ampah   +48 more
core   +1 more source

Management of Acinetobacter baumannii infection of burn wound with the evidence of sepsis

Indian Journal of Burns, 2019
Introduction: Acinetobacter baumannii infection of a burn wound is a serious infection causing significant morbidity and mortality. Clinical Presentation: Acinetobacter can cause wound colonization, infection, invasive sepsis, and with or without septic ...
K Mathangi Ramakrishnan, Bala Ramachandran, K G Ravikumar, K Ravikumar, Sulochana Putli, V Jayaraman, Mathivanan, Ravi, Arumugam Ganamani, Mary Babu   +9 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source