Results 71 to 80 of about 68,858 (291)

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Plerixafor for pathogen‐agnostic treatment in murine thigh infection and zebrafish sepsis

Clinical and Translational Science
Plerixafor is a CXCR4 antagonist approved in 2008 by the FDA for hematopoietic stem cell collection. Subsequently, plerixafor has shown promise as a potential pathogen‐agnostic immunomodulator in a variety of preclinical animal models.
Martin O. Evans, Darren M. Smith, Adrian T. Kress, Robert J. Nadeau, Daniel J. Selig, Diana Caridha, Ratanachat Racharaks, Thomas Langowski, Michael S. Madejczyk, Chance Carbaugh, David Saunders, Mark Widder, Jason De Meese, Patricia J. Lee, Jesse P. DeLuca   +14 more
doaj   +1 more source

Alcohol acute intoxication before sepsis impairs the wound healing of intestinal anastomosis: rat model of the abdominal trauma patient

World Journal of Emergency Surgery, 2012
Introduction Most trauma patients are drunk at the time of injury. Up to 2% of traumatized patients develop sepsis, which considerably increases their mortality.
Morais Pedro, Ribeiro Vinícius, Caetano de Farias Igor, Almeida Silva Luiz, Carneiro Fabiana, Russomano Veiga Joel, Batista de Sousa João   +6 more
doaj   +1 more source

Burns and biofilms: priority pathogens and in vivo models

npj Biofilms and Microbiomes, 2021
Burn wounds can create significant damage to human skin, compromising one of the key barriers to infection. The leading cause of death among burn wound patients is infection.
Evgenia Maslova, Lara Eisaiankhongi, Folke Sjöberg, Ronan R. McCarthy   +3 more
doaj   +1 more source

Fatores de risco para infecção de ferida cirúrgica no pós-operatório de colecistectomia. [PDF]

, 1996
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Tocoginecologia, Curso de Medicina, Florianópolis ...
Farias Júnior, José Orlando de
core  

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Sepsis in pregnancy [PDF]

, 2016
This chapter discusses sepsis in pregnancy, and outlines the causes, risk factors, symptoms, investigations, and management of maternal sepsis and postpartum infections such as endometritis, septic pelvic thrombophlebitis, urinary tract infections ...
S. Arulkumaran, Stergios K. Doumouchtsis, Austin Ugwumadu   +2 more
core   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Draft genome sequence of Elizabethkingia meningoseptica isolated from a traumatic wound [PDF]

, 2014
We report the draft genome assembly of Elizabethkingia meningoseptica strain 502. The sample was isolated from the wound of a repatriated military serviceperson who suffered major trauma from an improvised explosive device (IED), resulting in wounds with
Quick, Joshua, Loman, Nicholas J, Oppenheim, Beryl, Constantinidou, Chrystala, Pallen, Mark J, Pallen, Mark J., Loman, Nicholas J.   +6 more
core   +1 more source