Results 41 to 50 of about 195,165 (286)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Superabsorbent wound dressings: A literature review [PDF]
, 2013 Superabsorbent dressings are promoted for use on moderate to highly exudating wounds to absorb and retain fluid, thus reducing the risk of leakage and minimising the risk of maceration.
White, Richard +2 more
core +3 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
APPENDICULAR CARCINOID IN A VICTIM WITH SIMULTANEOUS CHEST AND ABDOMEN TRAUMA
Неотложная медицинская помощь, 2017 The article reports a clinical case of surgical therapy of a patient with simultaneous chest and abdomen trauma and carcinoid of the appendix.
E. V. Tatarinova, G. A. Nefedova
doaj +1 more source
War injuries of the blood vessels of the extremities [PDF]
Vojnosanitetski Pregled, 2002 Treatment results of 200 injured with the lesions of 282 magisterial blood vessels were analyzed. All were combat injuries, and the majority was caused by the fragments of explosive device.
Radulović Svetozar +4 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Comparison of Penetrating and Blunt Traumatic Diaphragmatic Injuries [PDF]
Journal of Trauma and Injury, 2019 Purpose Traumatic diaphragmatic injury (TDI) is no longer considered to be a rare condition in Korea. This study investigated differences in the prevalence of accompanying injuries and the prognosis in patients with traumatic diaphragmatic damage ...
Sang Su Lee +5 more
doaj +1 more source
PENETRATING WOUNDS OF THE EYEBALL. [PDF]
JAMA: The Journal of the American Medical Association, 1897 The title assigned to this paper is so comprehensive in its scope, that I do not presume to touch upon all the phases which it might present, but will endeavor to emphasize such points as present themselves to my mind with especial force after a careful review of the available literature on the subject.
openaire +2 more sources
The evidence supporting the use of honey as a wound dressing [PDF]
, 2006 Some clinicians are under the impression that there is little or no evidence to support the use of honey as a wound dressing. This impression is reinforced by it being concluded in systematic reviews that the evidence is not of a high standard.
Molan, Peter C., P. C. Molan
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source