Results 61 to 70 of about 819,049 (308)

Laryngeal Trauma

open access: yesBengal Journal of Otolaryngology and Head Neck Surgery, 2021
Introduction Laryngeal trauma can be an immediately life-threatening entity.  Failure to recognize such injuries and delay in securing the airway may have fatal results.
Gurbax Singh   +4 more
doaj  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Surgical technique of abdominal gunshot wound treatment in conditions of regional conflict [PDF]

open access: yesСаратовский научно-медицинский журнал, 2010
The article points out the results of treatment of penetrating gunshot wounds of abdomen in extreme ...
M.S. Gromov, A.Z. Kerimov
doaj  

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

open access: yesFEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Features of the course of penetrating thoracic wounds with intrathoracic foreign bodies

open access: yesУкраїнський журнал клінічної хірургії
Features of the course of penetrating thoracic wounds with intrathoracic foreign ...
I. D. Duzhyi   +5 more
doaj   +1 more source

SPECIFIC FEATURES OF MANAGEMENT TACTICS IN SEVERE CONCOMITANT INCISION WOUNDS OF THE HEART

open access: yesВестник анестезиологии и реаниматологии, 2018
Heart wounds are fairly rare, out of all chest penetrating wounds they make 5-7%. The main causes of lethal outcomes in cardiac incision wounds are massive blood loss, a combination of acute massive blood loss and cardiac tamponade, and isolated cardiac ...
I. M. Samokhvalov   +11 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan   +9 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng   +4 more
wiley   +1 more source

Brachiocephalic trunk and left brachiocephalic vein injuries following penetrating right sternoclavicular junction trauma: a case report

open access: yesChinese Journal of Traumatology, 2013
【Abstract】 A 46-year-old male sustained severe penetrating injury by a sharp instrument to his right upper sternoclavicular junction. The wound tract was from suprasternal notch to mediastinum.
KONG Ling-wen   +5 more
doaj  

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