Results 51 to 60 of about 19,936 (245)

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

An unusual case of penetrating head injury in a child

Journal of Emergencies, Trauma and Shock, 2010
Penetrating head injuries can be the result of numerous intentional or unintentional events, including missile wounds, stab wounds, and motor vehicle or occupational accidents (nails, screw-drivers).
Karim Tanweer, Topno Margaret
doaj  

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Unusual weapon of a murder case- A case of fatal penetrating chest trauma

Forensic Science International: Reports
To solve complex forensic cases, medico-legal issues such as cause of death, manner of death, weapon used, postmortem interval, and volitional activity must be resolved.
U. Mayorathan, M. Sriluxayini
doaj   +1 more source

Consideration of penetrating abdominal trauma, a retrospective study.

Albanian Journal of Trauma and Emergency Surgery, 2017
Background; Nowadays penetrating trauma is increasing because of the growth of violence in our society. The penetrating injury (PI) constitute about 6% of the hospitalized cases and 10% of visits to the emergency department (ED), they are calculated to ...
Agron Dogjani, Engjellushe Jonuzi, Fadil Gradica, Shkelzen Osmanaj, Eliziana Petrela   +4 more
doaj   +1 more source

Global and regional temporal changes in cross‐country inequalities of site‐specific osteoarthritis burden, 1990–2021

Arthritis Care &Research, Accepted Article.
Objective This study examined the global and regional temporal changes in cross‐country inequalities of site‐specific osteoarthritis (OA) burden from 1990 to 2021. Methods Age‐standardized years lived with disability rate for site‐specific OA across 204 countries/territories were obtained from the Global Burden of Diseases Study (GBD) 2021.
Haowei Chen, Lei Si, David J Hunter, Lei Zhang, Zhe‐Sheng Chen, Xiaomeng Wang, Vicky Duong, Zhounan Zhou, Peihua Cao, Han Cen, Su'an Tang, Tianyu Chen, Houjun Xue, Zhaohua Zhu, Changhai Ding   +14 more
wiley   +1 more source

Multiple Penetrating Eye Wounds Due to Suspected Self-Injury

Türk Oftalmoloji Dergisi, 2021
We present a case of a 29-year-old male night watchman complaining of sudden decreased vision, redness, and tearing of the left eye. On anamnesis, trauma was denied and personal past history was relevant for right eye enucleation due to an “eye injury” 8
José Dalma-Weiszhausz, José Arturo Oyervides Alvarado, Ana Maria Suarez Licona, Miriam Tatiana Serment Azuara, Alejandro Dalma Kende   +4 more
doaj   +1 more source

Complex penetrating cervical wound [PDF]

Trauma Surgery & Acute Care Open, 2019
A 24-year-old man presented to the trauma center with gunshot wounds to the neck, chest and back. The patient was awake but lethargic with a heart rate of 120 beats per minute, a systolic blood pressure of 80 mm Hg and absent breath sounds on the right.
Thomas M. Scalea, David V. Feliciano, Melike Harfouche   +2 more
openaire   +4 more sources

The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization

Advanced Biology, EarlyView.
This study explores the use of collagen‐hyaluronic acid (HA) hydrogels for the 3D culture of macrophages, providing a useful tool for modelling macrophage behavior in tissues and diseases. It highlights how hydrogel composition, mechanical properties, and preparation methods influence macrophage behavior, revealing for the first time that HA's ...
Tiah CL Oates, Jasmin Boyd, Louise Dolan, C de Kergariou, Jingwen Zhu, Ash Toye, Adam W Perriman, Asme Boussahel   +7 more
wiley   +1 more source