Results 91 to 100 of about 656,119 (315)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds
Frontiers in Pharmacology, 2018 Alarming data about increasing resistance to conventional antibiotics are reported, while at the same time the development of new antibiotics is stagnating.
Anja Pfalzgraff +2 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The use of manuka honey to promote wound healing [PDF]
, 2013 When wounds are not healing, or the healing is slow, this is usually because the wound is inflamed. Inflammation in a wound is also responsible for unsightly scars after a wound has eventually healed.
Molan, Peter C.
core +1 more source
Exploring Resilience When Living with a Wound — An Integrative Literature Review [PDF]
, 2014 The psychological impact for patients with wounds can be significant, and adverse psychological effects frequently occur when there are permanent changes in the body’s structure or function.
Edward, Karen-Leigh, Ousey, Karen
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
The Achievements of Trooper Mulloy [PDF]
, 2012 In the summer of 1900 Lorne Mulloy, a wounded Canadian soldier serving with the second Canadian contingent in South Africa, wrote from a military hospital in Johannesburg to his family about serious wounds to his eyes received in battle: “I have not ...
Schecter, Jack
core +1 more source
Phoenix dactylifera L. sap enhances wound healing in Wistar rats : Phytochemical and histological assessment [PDF]
, 2016 Acknowledgment Financial support of the Tunisian Ministry of Higher Education and Scientific Research is gratefully acknowledged.Peer ...
Abdennabi, Raed +8 more
core +3 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source