Results 91 to 100 of about 814,933 (365)

Human decellularized dermal matrix seeded with adipose-derived stem cells enhances wound healing in a murine model : experimental study [PDF]

, 2019
Objective: Full-thickness cutaneous wounds treated with split-thickness skin grafts often result in unaesthetic and hypertrophic scars. Dermal substitutes are currently used together with skin grafts in a single treatment to reconstruct the dermal layer ...
Amos, Anderson, Banyard, Blanton, Blecher, Cao, Davis, de Vries, Dominici, Foltynski, Foubert, Greenhalgh, Hendrickx, Holder, Huang, Jang, Kataoka, Kilkenny, Kilroy, Kim, Koh, Lu, Michaels, Moon, Nambu, Nguyen, Nie, Nie, Pirayesh, Rasband, Rowan, Seo, Sivan, Truong, Tsuboi, Wainwright, Wang, Zannettino   +37 more
core   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Pediatric Burn Treatment with Non-Thermal Atmospheric Plasma and Epifast^®: Clinical Results

European Burn Journal
The effective treatment of severe burns in pediatric patients is essential for minimizing complications and promoting optimal recovery. This study investigates the use of non-thermal atmospheric pressure plasma (NTAPP) as an adjuvant therapy in ...
Pablo Rodríguez-Ferreyra, Régulo López-Callejas, Teresa Narváez-Robles, Benjamín Gonzalo Rodríguez-Méndez, Omar Israel Gayosso-Cerón, Antonio Mercado-Cabrera, Irene Lule-Reyna, Othoniel Mondragón-Dagio, Raúl Valencia-Alvarado, Jesús Duarte-Mote   +9 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Diagnostic Accuracy of Abdominal wall Ultrasonography and Local Wound Exploration in Predicting the Need for Laparotomy following Stab Wound

Archives of Academic Emergency Medicine, 2016
Introduction: Screening of patients with anterior abdominal penetrating trauma in need for laparotomy is an important issue in management of these cases.
Ali Vafaei, Kamran Heidari, Afshin Saboorizadeh, Amin Shams Akhtari   +3 more
doaj   +1 more source

A two-compartment mechanochemical model of the roles of\ud transforming growth factor β and tissue tension in dermal wound healing [PDF]

, 2011
The repair of dermal tissue is a complex process of interconnected phenomena, where cellular, chemical and mechanical aspects all play a role, both in an autocrine and in a paracrine fashion.
Hall, C. L., Maini, P. K., McCue, S. W., McElwain, D. L. S., Murphy, K. E.   +4 more
core   +3 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Assessment of applicability of Ganga Hospital Score in the management of open tibia fracture

Bone & Joint Open
Aims: Open fractures of the tibia encompass a wide spectrum of injuries, posing multiple challenges for treating surgeons. This study evaluates the Ganga Hospital Open Injury Severity Score (GHOISS) in predicting the outcomes of open tibia fractures in ...
Innocent Kwizera, Jean C. Byiringiro, J. C. A. Ingabire, Emmanuel Murwanashyaka, Jean L. Mwizerwa   +4 more
doaj   +1 more source

Using honey to heal diabetic foot ulcers [PDF]

, 2008
Diabetic ulcers seem to be arrested in the inflammatory/proliferative stage of the healing process, allowing infection and inflammation to preclude healing.
Aaltonen, LA, Ballereau, S, Barclay, E, Broderick, P, Campbell, H, Carvajal-Carmona, LG, Casey, G, Cazier, JB, Chander, I, Cheadle, JP, Conti, D, Deary, I, Dobbins, SE, Domingo, E, Duggan, DJ, Dunlop, MG, Easton, D, Farrington, SM, Frampton, M, Gallinger, S, Gorman, M, Grimes, G, Henrion, M, Hopper, J, Houlston, RS, Jenkins, MA, Jones, AM, Kerr, DJ, Kirac, I, Kovacević, D, Lindblom, A, Liu, T, Lloyd, A, Lubbe, S, Ma, YP, Martin, L, Matsuda, K, Mecklin, JP, Midgley, R, Nakamura, Y, Newcomb, P, Okada, Y, Olver, B, Ooi, LY, Palles, C, Penegar, S, Pharoah, P, Prendergast, J, Renkonen-Sinisalo, L, Rudan, I, Schumacher, F, Semple, C, Shah, M, Smillie, C, Smith, CG, Spain, S, Starr, JM, Tenesa, A, Theodoratou, E, Tomlinson, IP, Vijayakrishnan, J, West, H, Whiffin, N, Zgaga, L   +63 more
core   +2 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source