Results 71 to 80 of about 251,564 (406)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Abordagem do trauma renal - artigo de revisão: review of the literature

Revista do Colégio Brasileiro de Cirurgiões
A incidência de traumatismo é uma realidade crescente nos dias de hoje. O acometimento dos reina ocorre em cerca de 10% dos pacientes com trauma abdominal fechado ou penetrante, podendo elevar muito a morbimortalidade quando não bem conduzido. Os autores
Lupércio Faria e Silva, Luiz Carlos Teixeira, João Baptista Rezende Neto   +2 more
doaj   +1 more source

Invisible Wounds of War Psychological and Cognitive Injuries, Their Consequences, and Services to Assist Recovery

The RAND Corporation is a nonprofit research organization providing objective analysis and effective solutions that address the challenges facing the public and private sectors around the world.
G. Marshall
semanticscholar   +1 more source

For Many Injured Veterans, A Lifetime of Consequences [PDF]

, 2011
One out of every ten veterans alive today was seriously injured at some point while serving in the military, and three-quarters of those injuries occurred in combat.
Ana Gonzalez, Eileen Patten, Paul Taylor, Rich Morin, Seth Motel   +4 more
core  

Outcomes and costs of penetrating trauma injury in England and Wales [PDF]

, 2008
The official published version of the article can be found at the link below.Background: Penetrating trauma injury is generally associated with higher short-term mortality than blunt trauma, and results in substantial societal costs given the young age ...
Christensen, MC, Lecky, FE, Morris, S, Nielsen, TG, Ridley, S   +4 more
core   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Adherence to national trauma triage criteria in Norway: a cross-sectional study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background Norwegian hospitals employed individual trauma triage criteria until 2015 when nationwide criteria were implemented. There is a lack of empirical evidence regarding adherence to Norwegian national criteria for activation of the trauma team ...
Einar Frigstad Hoås, Waleed Mohammed Majeed, Olav Røise, Oddvar Uleberg   +3 more
doaj   +1 more source

Traumatic globe avulsion secondary to a penetrating orbital injury from a bicycle handlebar: a case report [PDF]

Journal of Trauma and Injury
A 60-year-old man presented with total avulsion of the right globe following a penetrating injury to the right orbit from a metal bicycle handlebar. There was no light perception in the right eye on presentation.
Nishanth S. Iyengar, Edward Xie, Patricia Pahk, Nariman S. Boyle   +3 more
doaj   +1 more source

Tree of Life Synagogue Shooting in Pittsburgh: Preparedness, Prehospital Care, and Lessons Learned [PDF]

, 2020
On Saturday, October 27, 2018, a man with anti-Semitic motivations entered Tree of Life synagogue in the Squirrel Hill section of Pittsburgh, Pennsylvania; he had an AR-15 semi-automatic rifle and three handguns, opening fire upon worshippers. Eventually
Murray, Keith, Roth, Ronald N., Tobias, Adam Z., Weiss, Leonard S., Yealy, Donald M.   +4 more
core  

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source