Results 81 to 90 of about 90,734 (300)

Characteristics of Bone Injuries Resulting from Knife Wounds Incised with Different Forces

, 2017
The aim of this research was to experimentally determine the characteristics of incised bone wounds, which are commonly found in defense injuries. A specially constructed pivoting arm device was used to inflict wounds with controlled forces and direction.
Kumaratilake, J., Henneberg, M., Jaliya Kumaratilake, Humphrey, C., Caitlin Humphrey, Maciej Henneberg   +5 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

COMPARISON OF STANDARD NEGATIVE PRESSURE WOUND THERAPY ALONG WITH NEGATIVE PRESSURE WOUND THERAPY PLUS INSTILLATION OF NORMAL SALINE IN ACUTE TRAUMATIC WOUNDS

Pakistan Armed Forces Medical Journal, 2019
Objective: To compare the efficacy of standard negative pressure wound therapy with combination of negative pressure wound therapy (NPWT) and instillation of normal saline (NS) in acute traumatic wounds. Study Design: Randomized controlled trial.
Asad Maqbool, Muhammad Rizwan Aslam, Rao Saood Ahmed, Humza Mumtaz, Syed Iftikhar Ali, Usama Bin Zubair   +5 more
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Reconstruction of soft-tissue lesions of the foot with the use of the medial plantar flap

Revista Brasileira de Ortopedia
OBJECTIVE: To study use of the medial plantar flap for reconstruction of the heel and foot. METHOD: The authors share their clinical experience with the use of the medial plantar artery flap for coverage of tissue defects around the foot and heel ...
Jefferson Lessa Soares de Macedo, Simone Corrêa Rosa, Altino Vieira de Rezende Filho Neto, Adilson Alves da Silva, Alex Corcino Silva de Amorim   +4 more
doaj   +1 more source

Reconstructive challenges in war wounds

, 2012
War wounds are devastating with extensive soft tissue and osseous destruction and heavy contamination. War casualties generally reach the reconstructive surgery centre after a delayed period due to additional injuries to the vital organs.
Mrinal Kanti Mukherjee, Sanjay Maurya, Prem Singh Bhandari   +2 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Human Papillomavirus infection in oral and anogenital sites

DST, 2021
 Introduction: HPV infection causes cancer at several anatomical sites. However, the infection’s natural history in non-cervical sites is understudied.
Thaissa Isaias Cordeiro, Katia Cristina da Silva, Willker Menezes da Rocha, Daniele Ceperuelo Lisboa, Mauro Romero Leal Passos, Tegnus Depes de Gouvea, Charbell Miguel Kury, Silvia Maria Baeta Cavalcanti   +7 more
doaj  

Gunshot Injuries in American Trauma Centers: Analysis of the Lethality of Multiple Gunshot Wounds

, 2020
Introduction: Trauma center care and survival have been improving over the past several years. However, yearly firearm-related deaths have remained near constant at 33 000. One challenge to decreasing gunshot mortality is patients presenting with complex
Williams, Mallory, Nizam, Wasay, Cornwell, Edward E., Nonez, Harry, Ortega, Gezzer, Olufajo, Olubode A, Zeineddin, Ahmad, Olufajo, Olubode A., Haider, Adil, Haider, Adil H, Cornwell, Edward E, Gezzer Ortega, Adil Haider, Wasay Nizam, Mallory Williams, Edward E. Cornwell, Harry Nonez, Olubode A. Olufajo, Ahmad Zeineddin   +18 more
core   +1 more source