Results 91 to 100 of about 65,383 (222)
Europe and Turkey: identities in evolution. An analytical literature review. [PDF]
Open Res Eur, 2023 Gulmez SB, Topal AE, Rumelili B.
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Locked in and locked out: Covid-19 and teaching "remotely". [PDF]
Prospects (Paris), 2021 Strong-Wilson T, Yoder A.
europepmc +1 more source
Abstracts from the Thirteenth Annual Conference on Ethnic and Minority Studies [PDF]
, 1985 In on attempt to record a sense of the formal sessions at the 1985 Conference, the registration director asked Chairs to assemble abstracts and respondent comments from their sessions.
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Images for Iconoclasts: Images of Confucius in the Cultural Revolution
, 2007 Confucius died and was buried in 479 B.C.E., and he was never seen again. Or so one would think. “You may forget me as I once was,” Confucius reminds us in the Zhuangzi, but there is something unforgettable about me that will still live on. Confucius’s
Sommer, Deborah A., (司馬黛蘭)
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source