Results 151 to 160 of about 3,173,843 (314)
PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer +21 morewiley +1 more sourceClinical and laboratory markers to distinguish VEXAS from Schnitzler's syndrome: data from the AIDA network registries. [PDF]
Front Med (Lausanne)Caggiano V, Sbalchiero J, Frassi M, Martín-Nares E, Hinojosa-Azaola A, Sikora M, Jahnz-Różyk K, Crisafulli F, Franceschini F, Airò P, Guaracha-Basañez GA, Torres-Ruiz J, Sfriso P, Bindoli S, Baggio C, Hernández-Rodríguez J, Caverzaschi VG, Espinosa G, Mayrink Giardini HA, Alves Cordeiro R, González-García A, Peña Rodríguez M, Lopalco G, Iannone F, Viapiana O, Tufan A, Kucuk H, Hissaria P, Beecher M, De Paulis A, Mormile I, Dagna L, Campochiaro C, Gidaro A, La Cava L, Bugatti S, Milanesi A, Ruiz-Irastorza G, Piga M, Conti F, Moscato P, Opris-Belinski D, Vitetta R, Chighizola C, Recke A, Tornero-Romero F, Prete M, Govoni M, Emmi G, Kawakami-Campos PA, Triggianese P, Gurnari C, Ragab G, Balistreri A, Ziȩtkiewicz M, Wiesik-Szewczyk E, Frediani B, Fabiani C, Sicuranza A, Bocchia M, Cantarini L, Vitale A. +61 moreeuropepmc +1 more sourceCharacterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane +9 morewiley +1 more sourceBlinatumomab in de novo AYA ALL-Results of the Australasian Leukaemia and Lymphoma Group ALL09 "SUBLIME" study. [PDF]
HemasphereGreenwood M, Gangatharan S, Osborn M, Ng AP, Fleming S, Fedele P, Trahair T, Casey J, Mapp S, Cheung C, Armytage T, Henderson M, Sutton R, Rehn J, Page E, Heatley S, Button P, Rowley L, Larsen SR, Presgrave P, Kwan J, Bennett S, Fong CY, Dalla Pozza L, Yeung D, White D, Australasian Leukaemia and Lymphoma Group. +26 moreeuropepmc +1 more sourceBridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme +8 morewiley +1 more sourceAdenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski +14 morewiley +1 more source