Results 231 to 240 of about 3,173,843 (314)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Novel needle system for transmural access in therapeutic endoscopic ultrasound. [PDF]

Endoscopy
Mazza S, Scalvini D, Mauro A, Bardone M, Alfieri D, Torello Viera F, Anderloni A.   +6 more
europepmc   +1 more source

Designing Exposition in Content-Area Textbooks: A Bridge to Reading and Writing

, 1992
Susheela Abraham Varghese
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Replicating the unconscious working memory effect: a multisite Registered Report. [PDF]

Neurosci Conscious
Franco-Martínez A, Rey-Sáez R, Adrián-Ventura J, Amerio P, Baciero A, Bennis A, Bergström F, Cleeremans A, Contu L, Dell'Acqua R, Deng X, Dolu FN, Gambarota F, Gao Y, Garre-Frutos F, Grubert A, Hernando A, Hinojosa JA, Hoory A, Hou Z, Hung SM, Ito A, Jimenez M, Kosachenko AI, Kulaksız M, Lee DYH, Malas EM, Malejka S, Montoro PR, Mudrik L, Pavlov YG, Pesimena G, Prieto A, Rahnev D, Ringenberg L, Sandoval-Lentisco A, Sarodo A, Schreiber M, Sessa P, Solana P, Tarasov DA, Tortajada M, Xue K, Xue Z, Zheng Y, Çinici M, Shanks DR, Soto D, Vadillo MA.   +48 more
europepmc   +1 more source

THE USE OF SEMANTIC MAPPING STRATEGY TO FACILITATE STUDENTS’ VOCABULARY DEVELOPMENT IN PRE-WRITING ACTIVITY

, 2015
Ismet Laili Rachmawati
openalex   +1 more source

Rescue endoscopic ultrasound-guided hepaticogastrostomy with antegrade stenting for food-impacted complete papillary occlusion via intentional stent-mesh traversal. [PDF]

Endoscopy
Hara H, Ishii H, Katsumata R, Ashikawa T, Sakaki K, Yoshino K, Sakita S.   +6 more
europepmc   +1 more source

Total outflow facility before and after goniotomy in <i>ex vivo</i> perfusion models for aqueous humor dynamics: effect of periocular tissue. [PDF]

Front Med (Lausanne)
Kallab M, Kaltenboeck S, Panahi P, Hinterberger S, Bolz M, Huang AS, Strohmaier CA.   +6 more
europepmc   +1 more source