Results 51 to 60 of about 115,960 (208)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Unpacking the Impact of Writing Feedback Perception on Self-Regulated Writing Ability: The Role of Writing Self-Efficacy and Self-Regulated Learning Strategies

Behavioral Sciences
Writing is a goal-oriented cognitive activity that requires metacognition and is essential for learners across all academic levels. However, many students struggle with writing skills, which can negatively affect their academic success and future ...
Soonhee Hwang
doaj   +1 more source

The Implementation of Problem-Based Learning to Improve Students’ Writing Achievement in Argumentative Essay: Global Warming [PDF]

E3S Web of Conferences
Argumentative essays have long been used in the topic of teaching and learning writing. The current research investigated whether Problem-Based Learning on the topic of global warming could facilitate students to improve their writing achievement.
Shafamarwa Shalsa, Thahir Andi, Puspita Adelia, Istifa Pirka Faiza, Wiliyanti Vandan, Rhama Dhanny Devieka   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

HOW MIND MAPPING TECHNIQUE EFFECTIVE ON STUDENTS’ DESCRIPTIVE WRITING ACHIEVEMENT

Tell-us Journal
This study aims at analyzing the effectiveness of the mind mapping technique on students’ descriptive writing achievement. This research belongs to quasi experiment.
Maria Olga Jelimun
doaj   +1 more source

Teaching Essay Writing Using Authentic Materials to Improve Students' Writing Performance

JEES (Journal of English Educators Society), 2019
This study used authentic material as the tool in essay writing class. Authentic material is made not for teaching need; it is the material that bring real language knowledge. It can be brought to the class as a learning tool.
Ana Ahsana El-Sulukiyyah, Rasyidah Nur Aisyah   +1 more
doaj   +1 more source