Results 31 to 40 of about 112,677 (265)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Journal SampurasunThis research explores students' perceptions of implementing a Blended Learning model in an academic writing course to address challenges in foreign language academic writing.
Senny Suzanna Alwasilah
doaj +1 more source
Kajian Linguistik dan Sastra, 2016 This study aims at investigating the presence of correlation between comprehension of language elements and attitude towards Indonesian language with scientific paper writing competence.
Rian Apriliani
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
IJOTL-TL (Indonesian Journal of Language Teaching and Linguistics)This study investigates the relationship between lexical diversity (LD) and writing competence in English as a Foreign Language (EFL) among 66 Hungarian and 64 Jordanian university students.
Ahmad Naji, Ibrahim Rawshdeh
doaj +1 more source
Connections Between Children’s Motivations Toward Writing and Writing Competence
Journal of the Canadian Association for Curriculum Studies, 2020 This paper explores how young children’s motivation to engage in writing processes aligns with their demonstrated writing competencies. Additionally, it examines connections between children’s self-concept as writers and their writing performance. During group research sessions conducted over the course of four years, three cohorts of 336 children in ...
Kelli Finney, Maureen Hoskyn
openaire +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Journal of Language and Education, 2015 The main aim of the research is to examine professional L1 (Russian)/L2 (English) writing experiences among staff members of one Russian research-intensive university as well as to provide more insights into the universal pedagogies of professional ...
Natalia Smirnova
doaj +1 more source