Results 101 to 110 of about 2,057,027 (307)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2014 George Lober speaking on behalf of the Graduate Writing Center about the writing process.
Lober, George
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Profile: Issues in Teachers' Professional Development, 2011 Today it is necessary to approach environmental topics with students in an interdisciplinary manner to mitigate the environmental damages that the Earth is suffering.
Lorena Jaramillo Urrutia +1 more
doaj
Toughening and Healing of CFRPs by Diels-Alder-Based Nano-Modified Resin through Melt Electro-Writing Process Technique. [PDF]
Int J Mol Sci, 2022 Kotrotsos A +4 more
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
An evaluation of the writing component of the higher secondary English syllabus in Bangladesh [PDF]
This evaluation study sets out to investigate the effectiveness of the writing component of the Higher Secondary Certificate (HSC) English syllabus in Bangladesh.
Khan, Rubina
core
Exploiting screencasting and keylogging for L2 writing process instruction
, 2021 Following up on studies like Lindgren & Sullivan (2003) or Ranalli et al. (2018), this paper describes a pedagogical intervention aimed at making L2 learners of English aware of their writing process, by showing them how they actually go about writing a ...
Gilquin, Gaëtanelle +1 more
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Ho Chi Minh City Open University Journal of Science - Social Sciences, 2015 The current study aims to investigate the employment of self-regulated strategies (SRS) and the gender differences in using SRS in learners’ writing processes. Zimmerman’s model of selfregulated learning and thirty SRS are used.
Pham Vu Phi Ho, Nguyen Thi Kim Thanh
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