Results 101 to 110 of about 453,529 (294)

Written Culture in a Colonial Context. Africa and the Americas, 1500-1900

open access: yes, 2012
Previously published: UCT Press, 2011The circulation of manuscripts and books between different continents played a key role in the process of the first globalization from the 16th century onwards.

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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Histories of the Argentine Art in the 20th Century. Written Culture and Disciplinary History [PDF]

open access: yes, 2017
El presente artículo realiza un recorrido por historias generales del arte argentino publicadas en el siglo XX desde la perspectiva teórica de los estudios sobre cultura escrita. Se reflexiona sobre la historia del género en la Argentina como un lugar de
Pedroni, Juan Cruz
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Written culture in Peru

open access: yes, 2005
La lectura, la escritura y, en general, la cultura escrita, es fundamental para alcanzar mejores niveles de desarrollo y bienestar, tanto colectivos como individuales.
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Cultura escrita: práticas de leitura e do impresso

Written culture: reading pratices and printed book

open access: yes, 2009
A história da cultura escrita e das práticas de leitura é o tema discutido neste artigo. Visa compreender a trajetória do livro impresso em sua materialidade, bem como os processos delineados a partir da incontestável presença cultural e política desse ...
Lidia Eugenia Cavalcante
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Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

A trial of epic rules application on a text belonging written culture

open access: yes, 2010
Refî-i Âmidî, 1756’da Diyarbakır’da doğmuş, iyi eğitimli bir divan Şairidir. Divan ve Cân u Cânân olmak üzere iki eseri mevcuttur. Bu çalışmada Şeyh Galib’in Hüsn ü Aşk’ına nazire olarak yazılmış Cân u Cânân mesnevisi farklı bir açıdan ele alınacaktır ...
Mehtap Erdoğan
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