Results 111 to 120 of about 5,628,095 (258)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Written or living culture? [PDF]
Journal of the Anthropological Society of Oxford, 1990 Tony Free
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The beginnings of the written culture in Antiquity
Digithum, 2004 This paper proposes an analysis of writing as a system for communication, since its origins, in terms of its uses and socio-cultural context. We shall also look to review and comment on the way in which it has evolved in time and space and its primordial
M. Isabel Panosa
doaj
Participant 237 Community Conversations Written
, 2020 In this written interview, Participant 237 shares about challenges with remote learning and being an essential worker during the COVID-19 pandemic. The participant explains that they have a large family, with some family members who are immunocompromised,
La'Rissa
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Chiffres-clés Statistiques de la Culture et de la Communication 2025 [PDF]
Les Chiffres clés, statistiques de la culture et de la communication répondent aux besoins d’information chiffrée des acteurs de la culture et constituent un outil essentiel pour penser les enjeux qui traversent le secteur.
Ministère de la Culture
core
Curriculum-based measurement in written expression at the secondary level [PDF]
, 2003 Plan BThe use of curriculum-based measurement (CBM) in written expression is becoming more common in today’s schools; however, there is a need for more information pertaining to the technical adequacy of these measures at the secondary level. As a result,
Diercks, Barbara Ann
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source