Results 91 to 100 of about 453,529 (294)

A city almanac as research object of the history of written culture: Almanack da Parnahyba (1924-1982)

, 2018
This study concerns the Almanack da Parnahyba, a periodic book classified as a city almanac. Understood as a historical document, the immersion in its pages made it possible to construct some aspects as they are connected to the history of written ...
Jeferson Luís Marinho de Carvalho (5716844), Luciane Sgarbi Santos Grazziotin (5716847)   +1 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Written Culture [PDF]

, 1993
Also CSST Working Paper #96.http://deepblue.lib.umich.edu/bitstream/2027.42/51271/1/505 ...
Messick, Brinkley
core  

Anomie and written culture. Linguistic-ethnography survey on the relationship between 2011 revolution in Tunisia and the speaking writing of young Tunisians on Facebook

, 2021
Ce travail d’investigation est une enquête d’ethnographie linguistique pour penser et concevoir la relation entre deux notions : celle de la Révolution, cette mutation politique qui a eu lieu en Tunisie en 2011 (nous sommes là en face d’un problème ...
Tlili, Ameni
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Digital narratives on entrance exams for the Brazilian secondary school: ego-documents and written culture in history of the present time

, 2019
The proposal of this article is discussing digital narratives written in the first person, taken in their widest sense as ego-documents. We analyzed 12 blogs and 4 personal websites that provide written stories on entrance exams for the Brazilian ...
Silva, Cristiani Bereta da
core   +2 more sources

Written Ladakhi and the Future of Ladakh’s Culture

Forum for Linguistic Studies
This study explores Written Ladakhi and the future of Ladakh’s culture in the newly formed Union Territory of Ladakh, India. The Ladakhi language is at a critical pivotal period. Its survival in the next two generations depends directly on the introduction of the Ladakhi language in its written form in the educational system.
null Konchok Tashi, null Nicolas Tournadre, null Rebecca Norman   +2 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source