Results 131 to 140 of about 453,529 (294)

Cultura escrita y grupos profesionales: la escritura y la lectura entre los enfermos españoles de los siglos XVI y XVII

open access: yesHistoria. Instituciones. Documentos, 2004
La falta de buenas fuentes estadísticas seriadas hasta el siglo XIX hace que los estudios sobre alfabetización y cultura escrita en España tropiecen con serias dificultades, lo que obliga a la localización y análisis de fuentes de la más diversa ...
Antonio Claret García Martínez
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Gagauz religious manuscript tradition in the context of Moldavian ethnic and cultural influence (on the example of the origin of the Gagauz version of the Epistle on Sunday)

open access: yesRevista de Etnologie şi Culturologie, 2017
The religious handwritten tradition of the Gagauzians is investigated in this article. One of the most widespread among Gagauz people is the apocryphal tale of the New Testament – The Epistle About Lord’s Day (“The Epistle of Our Lord Jesus Christ ...
Elizaveta Kvilinkova
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Written Workplace Genres: Culture Variations

open access: yes, 2011
The business letter is the traditional mode of written communication in the world of work. But nowadays the fax, and more recently email, have taken over as the most common form of exchanging written messages. The obvious advantage of fax and email is that the exchange of messages is almost instantaneous.
Matić Ivušić, Tereza, Batoš, Silvija
openaire  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

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