Results 151 to 160 of about 5,628,095 (258)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Presumed <i>Candida tropicalis</i> endogenous endophthalmitis with multifocal systemic <i>Candida albicans</i> abscesses: a case report. [PDF]

Front Med (Lausanne)
Jingjing T, Nannan Y, Jingjie Z, Ping C, Yankun Z.   +4 more
europepmc   +1 more source

Rapport sur l\u27état de l\u27enseignement supérieur et de la recherche Culture - 2018 [PDF]

Le ministère de la Culture publie le premier Rapport sur l’état de l‘enseignement supérieur et de la recherche Culture. Ce rapport retrace les évolutions des dernières années dans les différents domaines de l’enseignement supérieur et de la recherche ...
Ministère de la Culture
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

"Ce que l’on détruit à Palmyre", Vincent Négri à réécouter sur France Culture

, 2015
Avant-hier, Vincent Négri et Nada Al-Hassan étaient les invités des Nouvelles vagues sur France Culture pour évoquer la destruction des sites patrimoniaux en Syrie.
Droit, patrimoine & culture
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Eduardo Neumann, Letra de Indios. Cultura escrita, comunicação e memória indígena nas Reduções do Paraguai

Nuevo mundo - Mundos Nuevos, 2018
Mickaël Orantin
doaj   +1 more source

Induced Membrane Reconstruction of a 6-cm Ulnar Defect With Concurrent Revision Bone Grafting of Radial Nonunion Following Gustilo-Anderson Type IIIB Open Forearm Fracture: A Case Report. [PDF]

Case Rep Orthop
Manfredi JN, Chandasir AB, Lomis M, Prenger B, Ali H, Urquhart-Foster K, Bischoff CJ, Ansari AA.   +7 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source