Results 71 to 80 of about 2,349,017 (306)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Stories from the walking library [PDF]

open access: yes, 2014
From August 17 to September 17, 2012, Deirdre Heddon and Misha Myers created and carried a Walking Library, made for the Sideways Arts Festival. Sideways, a festival ‘in the open' and 'on the go', aimed to connect ecology and culture through using the ...
Heddon, Deirdre, Myers, Misha
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Rey Chow. Ethics after idealism : theory-culture-ethnicity-reading; Xudong Zhang. Chinese modernism in the era of reforms : cultural fever, avant-garde fiction and the new Chinese cinema

open access: yes, 2000
This article reviews the books Ethics After Idealism: Theory-Culture-Ethnicity-Reading written by Rey Chow and Chinese Modernism in the Era of Reforms: Cultural Fever, Avant-Garde Fiction and the New Chinese Cinema written by Xudong ...
DONALD, Stephanie Hemelryk
core  

Poland in Times of Great War and Second Independence 1914–1939 [PDF]

open access: yes, 2015
The present book “Poland – History, Culture and Society. Selected Readings” is the third edition of a collection of academic texts written with the intention to accompany the module by providing incoming students with teaching materials that will assist ...
Pietrzak, Jacek
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Poland’s Integration with the European Union [PDF]

open access: yes, 2015
The present book “Poland – History, Culture and Society. Selected Readings” is the third edition of a collection of academic texts written with the intention to accompany the module by providing incoming students with teaching materials that will assist ...
Błaszczyk, Maria Celina
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Some Anti-Heretic Fragments in the 14th Century Bulgarian Canon Law Miscellanies [PDF]

open access: yes, 2014
It is well known that the major anti-heretic written source from the Second Bulgarian Empire is the Tsar Boril’s Synodicon, proved to have been compiled to serve the Synod against the Bogomils, convened in Tărnovo in 1211. However, the subsequent century
Tsibranska-Kostova, Mariyana
core   +1 more source

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