Results 41 to 50 of about 583,690 (214)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Teaching Argumentation in The Flipped Classroom of French as Foreign Language: What Are the Effects On the Development of Writing Skills?

Passerelle
More than ever before, pedagogical innovations, based mainly on the use of digital tools, are increasingly at the centre of didactic concerns. Within this scope, we propose to implement a flipped classroom with students enrolled in the first university ...
Nawal KHERRA, Ahlem AMER MEDJANI
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

PROCESAMIENTO DE LA PALABRA ESCRITA EN LA VEJEZ NORMAL PROCESSING OF THE WRITTEN WORD IN NORMAL AGING

Forma y Función, 2010
En esta investigación se analiza la escritura a mano de palabras aisladas en veinte adultos mayores (entre setenta y ochenta años de edad), para determinar si los efectos silábicos hallados en investigaciones previas sobre la escritura de personas ...
Alba Gallo, Silvia Baquero
doaj  

Expression de la spatialité dans l’interlangue d’apprenants arabophones du français LE [PDF]

Revue Roumaine d’Etudes Francophones, 2019
Non-Francophone learners make use of their LM more or less consciously when learning (FLE). Our analysis focuses on the narration of a filmic support. It consists in disentangling the expression of spatiality in the inter-language of our learners.
Feiza AICHOUR
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Diferenças na concordância verbal na narrativa de crianças de níveis socioculturais distintos Differences in verbal agreement in written narrative by children from different socio-cultural levels

Revista Brasileira de Linguística Aplicada, 2012
O principal objetivo deste artigo é verificar se há diferenças significativas entre concordância e não concordância no uso do sistema verbal na narrativa escrita de crianças que vivem em ambientes socioculturais distintos.
Lidiomar José Mascarello
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source